ROLE OF GRANULOCYTE COLONY-STIMULATING FACTOR (GCSF)/FILGRASTIM AS AN ADJUNCT IN CHRONIC HEPATITIS C MANAGEMENT
Drug-induced hematotoxicity is the commonest reason for reducing the dose or withdrawing interferon (IFN) therapy in a case o f chronic hepatitis C thus depriving the patient o f a possible cure. Traditionally, severe neutropenia has been considered an absolute contraindication to start antiviral t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Dow University of Health Sciences
2009-06-01
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| Series: | Journal of the Dow University of Health Sciences |
| Subjects: | |
| Online Access: | https://jduhs.com/index.php/jduhs/article/view/1331 |
| Summary: | Drug-induced hematotoxicity is the commonest reason for reducing the dose or withdrawing interferon (IFN) therapy in a case o f chronic hepatitis C thus depriving the patient o f a possible cure. Traditionally, severe neutropenia has been considered an absolute contraindication to start antiviral therapy. Since the advent o f adjunct therapy with Granulocyte-colony stimulating factor, the same is not true any more. Some recent landmark studies have used this adjunct therapy to help avoid antiviral dose reductions. Although, addition o f this adjunct therapy has been shown to significantly increase the overall cost o f the treatment,
if the infection is cured at the end o f the day, this extra cost is worth bearing. Although, more studies are needed to refine the true indications o f this adjunct therapy, determine the best dose regimen, quantify the average extra cost and validate that whether or not the addition o f this therapy increases the sustained virologic response rates achieved, the initial reports are encouraging. Therefore, although not recommended on routine basis, some selected patients may be given the benefits o f these factors. In this article, a review o f the current literature on this subject is given followed by few suggested recommendations at the end to help develop local guidelines.
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| ISSN: | 1995-2198 2410-2180 |