Amino Acid-Related Metabolic Signature in Obese Children and Adolescents
The growing interest in metabolomics has spread to the search for suitable predictive biomarkers for complications related to the emerging issue of pediatric obesity and its related cardiovascular risk and metabolic alteration. Indeed, several studies have investigated the association between metabo...
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MDPI AG
2022-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/7/1454 |
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| author | Nella Polidori Eleonora Agata Grasso Francesco Chiarelli Cosimo Giannini |
| author_facet | Nella Polidori Eleonora Agata Grasso Francesco Chiarelli Cosimo Giannini |
| author_sort | Nella Polidori |
| collection | DOAJ |
| description | The growing interest in metabolomics has spread to the search for suitable predictive biomarkers for complications related to the emerging issue of pediatric obesity and its related cardiovascular risk and metabolic alteration. Indeed, several studies have investigated the association between metabolic disorders and amino acids, in particular branched-chain amino acids (BCAAs). We have performed a revision of the literature to assess the role of BCAAs in children and adolescents’ metabolism, focusing on the molecular pathways involved. We searched on Pubmed/Medline, including articles published until February 2022. The results have shown that plasmatic levels of BCAAs are impaired already in obese children and adolescents. The relationship between BCAAs, obesity and the related metabolic disorders is explained on one side by the activation of the mTORC1 complex—that may promote insulin resistance—and on the other, by the accumulation of toxic metabolites, which may lead to mitochondrial dysfunction, stress kinase activation and damage of pancreatic cells. These compounds may help in the precocious identification of many complications of pediatric obesity. However, further studies are still needed to better assess if BCAAs may be used to screen these conditions and if any other metabolomic compound may be useful to achieve this goal. |
| first_indexed | 2024-03-09T11:32:58Z |
| format | Article |
| id | doaj.art-cbd8186405d64b3b9012227298e60c39 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:32:58Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-cbd8186405d64b3b9012227298e60c392023-11-30T23:48:28ZengMDPI AGNutrients2072-66432022-03-01147145410.3390/nu14071454Amino Acid-Related Metabolic Signature in Obese Children and AdolescentsNella Polidori0Eleonora Agata Grasso1Francesco Chiarelli2Cosimo Giannini3Department of Pediatrics, University of Chieti, Via dei Vestini 5, 66100 Chieti, ItalyDepartment of Pediatrics, University of Chieti, Via dei Vestini 5, 66100 Chieti, ItalyDepartment of Pediatrics, University of Chieti, Via dei Vestini 5, 66100 Chieti, ItalyDepartment of Pediatrics, University of Chieti, Via dei Vestini 5, 66100 Chieti, ItalyThe growing interest in metabolomics has spread to the search for suitable predictive biomarkers for complications related to the emerging issue of pediatric obesity and its related cardiovascular risk and metabolic alteration. Indeed, several studies have investigated the association between metabolic disorders and amino acids, in particular branched-chain amino acids (BCAAs). We have performed a revision of the literature to assess the role of BCAAs in children and adolescents’ metabolism, focusing on the molecular pathways involved. We searched on Pubmed/Medline, including articles published until February 2022. The results have shown that plasmatic levels of BCAAs are impaired already in obese children and adolescents. The relationship between BCAAs, obesity and the related metabolic disorders is explained on one side by the activation of the mTORC1 complex—that may promote insulin resistance—and on the other, by the accumulation of toxic metabolites, which may lead to mitochondrial dysfunction, stress kinase activation and damage of pancreatic cells. These compounds may help in the precocious identification of many complications of pediatric obesity. However, further studies are still needed to better assess if BCAAs may be used to screen these conditions and if any other metabolomic compound may be useful to achieve this goal.https://www.mdpi.com/2072-6643/14/7/1454BCAAsobesitypediatricsNAFLDinsulin resistance |
| spellingShingle | Nella Polidori Eleonora Agata Grasso Francesco Chiarelli Cosimo Giannini Amino Acid-Related Metabolic Signature in Obese Children and Adolescents Nutrients BCAAs obesity pediatrics NAFLD insulin resistance |
| title | Amino Acid-Related Metabolic Signature in Obese Children and Adolescents |
| title_full | Amino Acid-Related Metabolic Signature in Obese Children and Adolescents |
| title_fullStr | Amino Acid-Related Metabolic Signature in Obese Children and Adolescents |
| title_full_unstemmed | Amino Acid-Related Metabolic Signature in Obese Children and Adolescents |
| title_short | Amino Acid-Related Metabolic Signature in Obese Children and Adolescents |
| title_sort | amino acid related metabolic signature in obese children and adolescents |
| topic | BCAAs obesity pediatrics NAFLD insulin resistance |
| url | https://www.mdpi.com/2072-6643/14/7/1454 |
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