Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testing
While advanced imaging strategies have improved the diagnosis of bone-related pathologies, early signs of bone alterations remain difficult to detect. The Covid-19 pandemic has brought attention to the need for a better understanding of bone micro-scale toughening and weakening phenomena. This study...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2023-07-01
|
Series: | Materials & Design |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523005026 |
_version_ | 1797794029230882816 |
---|---|
author | Federica Buccino Luigi Zagra Elena Longo Lorenzo D'Amico Giuseppe Banfi Filippo Berto Giuliana Tromba Laura Maria Vergani |
author_facet | Federica Buccino Luigi Zagra Elena Longo Lorenzo D'Amico Giuseppe Banfi Filippo Berto Giuliana Tromba Laura Maria Vergani |
author_sort | Federica Buccino |
collection | DOAJ |
description | While advanced imaging strategies have improved the diagnosis of bone-related pathologies, early signs of bone alterations remain difficult to detect. The Covid-19 pandemic has brought attention to the need for a better understanding of bone micro-scale toughening and weakening phenomena. This study used an artificial intelligence-based tool to automatically investigate and validate four clinical hypotheses by examining osteocyte lacunae on a large scale with synchrotron image-guided failure assessment. The findings indicate that trabecular bone features exhibit intrinsic variability related to external loading, micro-scale bone characteristics affect fracture initiation and propagation, osteoporosis signs can be detected at the micro-scale through changes in osteocyte lacunar features, and Covid-19 worsens micro-scale porosities in a statistically significant manner similar to the osteoporotic condition. Incorporating these findings with existing clinical and diagnostic tools could prevent micro-scale damages from progressing into critical fractures. |
first_indexed | 2024-03-13T02:56:56Z |
format | Article |
id | doaj.art-cbd91380e40e427db12ea69f2a181f3c |
institution | Directory Open Access Journal |
issn | 0264-1275 |
language | English |
last_indexed | 2024-03-13T02:56:56Z |
publishDate | 2023-07-01 |
publisher | Elsevier |
record_format | Article |
series | Materials & Design |
spelling | doaj.art-cbd91380e40e427db12ea69f2a181f3c2023-06-28T04:28:45ZengElsevierMaterials & Design0264-12752023-07-01231112087Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testingFederica Buccino0Luigi Zagra1Elena Longo2Lorenzo D'Amico3Giuseppe Banfi4Filippo Berto5Giuliana Tromba6Laura Maria Vergani7Department of Mechanical Engineering, Politecnico di Milano, 20156, ItalyI.R.C.C.S Ospedale Galeazzi - Sant'Ambrogio, Milano 20157, ItalyElettra-Sincrotrone Trieste SCpA, Basovizza, Trieste 34149, ItalyElettra-Sincrotrone Trieste SCpA, Basovizza, Trieste 34149, ItalyI.R.C.C.S Ospedale Galeazzi - Sant'Ambrogio, Milano 20157, ItalyUniversità La Sapienza, Rome 00185, Italy; NTNU, NorwayElettra-Sincrotrone Trieste SCpA, Basovizza, Trieste 34149, ItalyDepartment of Mechanical Engineering, Politecnico di Milano, 20156, Italy; Corresponding author at: Via La Masa 1, 20156 Milano, Italy.While advanced imaging strategies have improved the diagnosis of bone-related pathologies, early signs of bone alterations remain difficult to detect. The Covid-19 pandemic has brought attention to the need for a better understanding of bone micro-scale toughening and weakening phenomena. This study used an artificial intelligence-based tool to automatically investigate and validate four clinical hypotheses by examining osteocyte lacunae on a large scale with synchrotron image-guided failure assessment. The findings indicate that trabecular bone features exhibit intrinsic variability related to external loading, micro-scale bone characteristics affect fracture initiation and propagation, osteoporosis signs can be detected at the micro-scale through changes in osteocyte lacunar features, and Covid-19 worsens micro-scale porosities in a statistically significant manner similar to the osteoporotic condition. Incorporating these findings with existing clinical and diagnostic tools could prevent micro-scale damages from progressing into critical fractures.http://www.sciencedirect.com/science/article/pii/S0264127523005026Bone lacunaeMicro-scaleSynchrotronOsteoporosisCovid-19 |
spellingShingle | Federica Buccino Luigi Zagra Elena Longo Lorenzo D'Amico Giuseppe Banfi Filippo Berto Giuliana Tromba Laura Maria Vergani Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testing Materials & Design Bone lacunae Micro-scale Synchrotron Osteoporosis Covid-19 |
title | Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testing |
title_full | Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testing |
title_fullStr | Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testing |
title_full_unstemmed | Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testing |
title_short | Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testing |
title_sort | osteoporosis and covid 19 detected similarities in bone lacunar level alterations via combined ai and advanced synchrotron testing |
topic | Bone lacunae Micro-scale Synchrotron Osteoporosis Covid-19 |
url | http://www.sciencedirect.com/science/article/pii/S0264127523005026 |
work_keys_str_mv | AT federicabuccino osteoporosisandcovid19detectedsimilaritiesinbonelacunarlevelalterationsviacombinedaiandadvancedsynchrotrontesting AT luigizagra osteoporosisandcovid19detectedsimilaritiesinbonelacunarlevelalterationsviacombinedaiandadvancedsynchrotrontesting AT elenalongo osteoporosisandcovid19detectedsimilaritiesinbonelacunarlevelalterationsviacombinedaiandadvancedsynchrotrontesting AT lorenzodamico osteoporosisandcovid19detectedsimilaritiesinbonelacunarlevelalterationsviacombinedaiandadvancedsynchrotrontesting AT giuseppebanfi osteoporosisandcovid19detectedsimilaritiesinbonelacunarlevelalterationsviacombinedaiandadvancedsynchrotrontesting AT filippoberto osteoporosisandcovid19detectedsimilaritiesinbonelacunarlevelalterationsviacombinedaiandadvancedsynchrotrontesting AT giulianatromba osteoporosisandcovid19detectedsimilaritiesinbonelacunarlevelalterationsviacombinedaiandadvancedsynchrotrontesting AT lauramariavergani osteoporosisandcovid19detectedsimilaritiesinbonelacunarlevelalterationsviacombinedaiandadvancedsynchrotrontesting |