Inflammasome activation leads to cDC1-independent cross-priming of CD8 T cells by epithelial cell-derived antigen

Inflammasome activation leads to cDC1-independent cross-priming of CD8 T cells by epithelial cell-derived antigen

The innate immune system detects pathogens and initiates adaptive immune responses. Inflammasomes are central components of the innate immune system, but whether inflammasomes provide sufficient signals to activate adaptive immunity is unclear. In intestinal epithelial cells (IECs), inflammasomes ac...

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Bibliographic Details
Main Authors: Katherine A Deets, Randilea Nichols Doyle, Isabella Rauch, Russell E Vance
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
inflammasome
antigen presentation
intestinal epithelial cells
adaptive immunity
Online Access:https://elifesciences.org/articles/72082

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