Poor adherence to and persistence with biologics in generalized pustular psoriasis: A claim-based study using real-world data from two large US databasesCapsule Summary
Background: Generalized pustular psoriasis (GPP) is a rare skin disease characterized by episodes of widespread sterile pustules. Methods: A retrospective cohort study using data from the US IBM MarketScan Commercial and Optum Clinformatics Data Mart databases between October 1, 2015 and March 31, 2...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | JAAD International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666328724000051 |
| _version_ | 1797289695245238272 |
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| author | Steven R. Feldman, MD Rhonda L. Bohn, ScD Ran Gao, MS Stephani Gray, MPH Sabrina E. Walton, MSPH Anouk Déruaz-Luyet, PhD, MPH Jashin J. Wu, MD |
| author_facet | Steven R. Feldman, MD Rhonda L. Bohn, ScD Ran Gao, MS Stephani Gray, MPH Sabrina E. Walton, MSPH Anouk Déruaz-Luyet, PhD, MPH Jashin J. Wu, MD |
| author_sort | Steven R. Feldman, MD |
| collection | DOAJ |
| description | Background: Generalized pustular psoriasis (GPP) is a rare skin disease characterized by episodes of widespread sterile pustules. Methods: A retrospective cohort study using data from the US IBM MarketScan Commercial and Optum Clinformatics Data Mart databases between October 1, 2015 and March 31, 2020 was performed to describe adherence and persistence to biologics in patients with GPP. Patients were aged ≥18 years with newly diagnosed GPP (International Classification of Diseases code L40.1) and had ≥1 inpatient or ≥2 outpatient claims. Results: Biologics were dispensed to 110 of 502 (22%) and 73 of 528 (14%) patients from MarketScan and Optum databases, respectively. The mean proportion of days covered (PDC) (range) was similar in both databases (MarketScan, 65% [8%-100%]; Optum, 59% [8%-99%]), and good adherence (≥80% PDC) was uncommon (MarketScan, 36%; Optum, 24%). Mean (standard deviation) persistence was similar in both databases (MarketScan, 287 [122] days; Optum, 261 [134] days). In Optum, the mean PDC was similar between age categories; good adherence was more common in patients aged 18 to 64 years (28%) versus ≥65 years (13%). Mean persistence was longer in patients aged 18 to 64 years (267 days) versus ≥65 years (242 days). Conclusions: Overall, adherence and persistence were generally poor and varied according to the biologic class, database, and age. Improving adherence may help improve GPP treatment outcomes. |
| first_indexed | 2024-03-07T19:08:46Z |
| format | Article |
| id | doaj.art-cbdb8723cce74115b9e0c473d1bfc3ca |
| institution | Directory Open Access Journal |
| issn | 2666-3287 |
| language | English |
| last_indexed | 2024-03-07T19:08:46Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JAAD International |
| spelling | doaj.art-cbdb8723cce74115b9e0c473d1bfc3ca2024-03-01T05:07:19ZengElsevierJAAD International2666-32872024-06-01157883Poor adherence to and persistence with biologics in generalized pustular psoriasis: A claim-based study using real-world data from two large US databasesCapsule SummarySteven R. Feldman, MD0Rhonda L. Bohn, ScD1Ran Gao, MS2Stephani Gray, MPH3Sabrina E. Walton, MSPH4Anouk Déruaz-Luyet, PhD, MPH5Jashin J. Wu, MD6Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Correspondence to: Dr Steven R. Feldman, MD, Department of Dermatology, Wake Forest University School of Medicine, 4618 Country Club Road, Winston-Salem, NC 27104.Bohn Epidemiology, Boston, MassachusettsBoehringer Ingelheim Pharmaceuticals Inc., Ridgefield, ConnecticutBohn Epidemiology, Boston, MassachusettsBoehringer Ingelheim Pharmaceuticals Inc., Ridgefield, ConnecticutBoehringer Ingelheim International GmbH, Ingelheim, GermanyDepartment of Dermatology, University of Miami, Miller School of Medicine, Miami, FloridaBackground: Generalized pustular psoriasis (GPP) is a rare skin disease characterized by episodes of widespread sterile pustules. Methods: A retrospective cohort study using data from the US IBM MarketScan Commercial and Optum Clinformatics Data Mart databases between October 1, 2015 and March 31, 2020 was performed to describe adherence and persistence to biologics in patients with GPP. Patients were aged ≥18 years with newly diagnosed GPP (International Classification of Diseases code L40.1) and had ≥1 inpatient or ≥2 outpatient claims. Results: Biologics were dispensed to 110 of 502 (22%) and 73 of 528 (14%) patients from MarketScan and Optum databases, respectively. The mean proportion of days covered (PDC) (range) was similar in both databases (MarketScan, 65% [8%-100%]; Optum, 59% [8%-99%]), and good adherence (≥80% PDC) was uncommon (MarketScan, 36%; Optum, 24%). Mean (standard deviation) persistence was similar in both databases (MarketScan, 287 [122] days; Optum, 261 [134] days). In Optum, the mean PDC was similar between age categories; good adherence was more common in patients aged 18 to 64 years (28%) versus ≥65 years (13%). Mean persistence was longer in patients aged 18 to 64 years (267 days) versus ≥65 years (242 days). Conclusions: Overall, adherence and persistence were generally poor and varied according to the biologic class, database, and age. Improving adherence may help improve GPP treatment outcomes.http://www.sciencedirect.com/science/article/pii/S2666328724000051adherencebiologicsclaims studygeneralized pustular psoriasispersistencepsoriasis |
| spellingShingle | Steven R. Feldman, MD Rhonda L. Bohn, ScD Ran Gao, MS Stephani Gray, MPH Sabrina E. Walton, MSPH Anouk Déruaz-Luyet, PhD, MPH Jashin J. Wu, MD Poor adherence to and persistence with biologics in generalized pustular psoriasis: A claim-based study using real-world data from two large US databasesCapsule Summary JAAD International adherence biologics claims study generalized pustular psoriasis persistence psoriasis |
| title | Poor adherence to and persistence with biologics in generalized pustular psoriasis: A claim-based study using real-world data from two large US databasesCapsule Summary |
| title_full | Poor adherence to and persistence with biologics in generalized pustular psoriasis: A claim-based study using real-world data from two large US databasesCapsule Summary |
| title_fullStr | Poor adherence to and persistence with biologics in generalized pustular psoriasis: A claim-based study using real-world data from two large US databasesCapsule Summary |
| title_full_unstemmed | Poor adherence to and persistence with biologics in generalized pustular psoriasis: A claim-based study using real-world data from two large US databasesCapsule Summary |
| title_short | Poor adherence to and persistence with biologics in generalized pustular psoriasis: A claim-based study using real-world data from two large US databasesCapsule Summary |
| title_sort | poor adherence to and persistence with biologics in generalized pustular psoriasis a claim based study using real world data from two large us databasescapsule summary |
| topic | adherence biologics claims study generalized pustular psoriasis persistence psoriasis |
| url | http://www.sciencedirect.com/science/article/pii/S2666328724000051 |
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