Bone Morphogenetic Protein 4 Targeting Glioma Stem-Like Cells for Malignant Glioma Treatment: Latest Advances and Implications for Clinical Application

Bone Morphogenetic Protein 4 Targeting Glioma Stem-Like Cells for Malignant Glioma Treatment: Latest Advances and Implications for Clinical Application

Malignant gliomas are heterogeneous neoplasms. Glioma stem-like cells (GSCs) are undifferentiated and self-renewing cells that develop and maintain these tumors. These cells are the main population that resist current therapies. Genomic and epigenomic analyses has identified various molecular subtyp...

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Bibliographic Details
Main Authors: Sonali Nayak, Ashorne Mahenthiran, Yongyong Yang, Mark McClendon, Barbara Mania-Farnell, Charles David James, John A. Kessler, Tadanori Tomita, Shi-Yuan Cheng, Samuel I. Stupp, Guifa Xi
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
bone morphogenetic protein 4
molecular mechanism
delivery
clinical application
malignant glioma
Online Access:https://www.mdpi.com/2072-6694/12/2/516

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