Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability
Consolation is a common response to the distress of others in humans and some social animals, but the neural mechanisms underlying this behavior are not well characterized. By using socially monogamous mandarin voles, we found that optogenetic or chemogenetic inhibition of 5-HTergic neurons in the d...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2021-06-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/67638 |
| _version_ | 1811180567560978432 |
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| author | Laifu Li Li-Zi Zhang Zhi-Xiong He Huan Ma Yu-Ting Zhang Yu-Feng Xun Wei Yuan Wen-Juan Hou Yi-Tong Li Zi-Jian Lv Rui Jia Fa-Dao Tai |
| author_facet | Laifu Li Li-Zi Zhang Zhi-Xiong He Huan Ma Yu-Ting Zhang Yu-Feng Xun Wei Yuan Wen-Juan Hou Yi-Tong Li Zi-Jian Lv Rui Jia Fa-Dao Tai |
| author_sort | Laifu Li |
| collection | DOAJ |
| description | Consolation is a common response to the distress of others in humans and some social animals, but the neural mechanisms underlying this behavior are not well characterized. By using socially monogamous mandarin voles, we found that optogenetic or chemogenetic inhibition of 5-HTergic neurons in the dorsal raphe nucleus (DR) or optogenetic inhibition of serotonin (5-HT) terminals in the anterior cingulate cortex (ACC) significantly decreased allogrooming time in the consolation test and reduced sociability in the three-chamber test. The release of 5-HT within the ACC and the activity of DR neurons were significantly increased during allogrooming, sniffing, and social approaching. Finally, we found that the activation of 5-HT1A receptors in the ACC was sufficient to reverse consolation and sociability deficits induced by the chemogenetic inhibition of 5-HTergic neurons in the DR. Our study provided the first direct evidence that DR-ACC 5-HTergic neural circuit is implicated in consolation-like behaviors and sociability. |
| first_indexed | 2024-04-11T09:05:27Z |
| format | Article |
| id | doaj.art-cbddec1f36954c11becb22923c3b6ff2 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:05:27Z |
| publishDate | 2021-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-cbddec1f36954c11becb22923c3b6ff22022-12-22T04:32:39ZengeLife Sciences Publications LtdeLife2050-084X2021-06-011010.7554/eLife.67638Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociabilityLaifu Li0Li-Zi Zhang1Zhi-Xiong He2Huan Ma3Yu-Ting Zhang4Yu-Feng Xun5Wei Yuan6Wen-Juan Hou7Yi-Tong Li8Zi-Jian Lv9Rui Jia10Fa-Dao Tai11https://orcid.org/0000-0002-6804-4179Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an, China; College of Life Sciences, Nanyang Normal University, Nanyang, ChinaInstitute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an, ChinaInstitute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an, ChinaInstitute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an, ChinaInstitute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an, ChinaInstitute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an, ChinaInstitute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an, China; Provincial Key Laboratory of Acupuncture and Medications, Shaanxi University of Chinese Medicine, Xianyang, ChinaInstitute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an, ChinaInstitute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an, ChinaInstitute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an, ChinaInstitute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an, ChinaInstitute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an, ChinaConsolation is a common response to the distress of others in humans and some social animals, but the neural mechanisms underlying this behavior are not well characterized. By using socially monogamous mandarin voles, we found that optogenetic or chemogenetic inhibition of 5-HTergic neurons in the dorsal raphe nucleus (DR) or optogenetic inhibition of serotonin (5-HT) terminals in the anterior cingulate cortex (ACC) significantly decreased allogrooming time in the consolation test and reduced sociability in the three-chamber test. The release of 5-HT within the ACC and the activity of DR neurons were significantly increased during allogrooming, sniffing, and social approaching. Finally, we found that the activation of 5-HT1A receptors in the ACC was sufficient to reverse consolation and sociability deficits induced by the chemogenetic inhibition of 5-HTergic neurons in the DR. Our study provided the first direct evidence that DR-ACC 5-HTergic neural circuit is implicated in consolation-like behaviors and sociability.https://elifesciences.org/articles/67638consolationempathyanterior cingulate cortexserotoninmandarin volesdorsal raphe nucleus |
| spellingShingle | Laifu Li Li-Zi Zhang Zhi-Xiong He Huan Ma Yu-Ting Zhang Yu-Feng Xun Wei Yuan Wen-Juan Hou Yi-Tong Li Zi-Jian Lv Rui Jia Fa-Dao Tai Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability eLife consolation empathy anterior cingulate cortex serotonin mandarin voles dorsal raphe nucleus |
| title | Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability |
| title_full | Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability |
| title_fullStr | Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability |
| title_full_unstemmed | Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability |
| title_short | Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability |
| title_sort | dorsal raphe nucleus to anterior cingulate cortex 5 htergic neural circuit modulates consolation and sociability |
| topic | consolation empathy anterior cingulate cortex serotonin mandarin voles dorsal raphe nucleus |
| url | https://elifesciences.org/articles/67638 |
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