SphK-produced S1P in somatic cells is indispensable for LH-EGFR signaling-induced mouse oocyte maturation

SphK-produced S1P in somatic cells is indispensable for LH-EGFR signaling-induced mouse oocyte maturation

Abstract Germ cell division and differentiation require intimate contact and interaction with the surrounding somatic cells. Luteinizing hormone (LH) triggers epidermal growth factor (EGF)-like growth factors to promote oocyte maturation and developmental competence by activating EGF receptor (EGFR)...

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Bibliographic Details
Main Authors: Feifei Yuan, Xiaoqiong Hao, Yanying Cui, FuXin Huang, Xiaodan Zhang, Yanli Sun, Tiantian Hao, Zhijuan Wang, Wei Xia, Youqiang Su, Meijia Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2022-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05415-2

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