High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling Pathway
Liver cancer is the fourth leading cause of cancer-related death globally, accounting for approximately 800,000 deaths annually. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, making up about 80% of cases. Liver fibrosis and its end-stage disease, cirrhosis, are major risk f...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/20/3/581 |
| _version_ | 1798045071633809408 |
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| author | Hyuk Moon Kyungjoo Cho Sunyeong Shin Do Young Kim Kwang-Hyub Han Simon Weonsang Ro |
| author_facet | Hyuk Moon Kyungjoo Cho Sunyeong Shin Do Young Kim Kwang-Hyub Han Simon Weonsang Ro |
| author_sort | Hyuk Moon |
| collection | DOAJ |
| description | Liver cancer is the fourth leading cause of cancer-related death globally, accounting for approximately 800,000 deaths annually. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, making up about 80% of cases. Liver fibrosis and its end-stage disease, cirrhosis, are major risk factors for HCC. A fibrotic liver typically shows persistent hepatocyte death and compensatory regeneration, chronic inflammation, and an increase in reactive oxygen species, which collaboratively create a tumor-promoting microenvironment via inducing genetic alterations and chromosomal instability, and activating various oncogenic molecular signaling pathways. In this article, we review recent advances in fields of liver fibrosis and carcinogenesis, and consider several molecular signaling pathways that promote hepato-carcinogenesis under the microenvironment of liver fibrosis. In particular, we pay attention to emerging roles of the Hippo-YAP/TAZ signaling pathway in stromal activation, hepatic fibrosis, and liver cancer. |
| first_indexed | 2024-04-11T23:14:44Z |
| format | Article |
| id | doaj.art-cbde99f441c54eb1be98470ae7a2ee82 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-11T23:14:44Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-cbde99f441c54eb1be98470ae7a2ee822022-12-22T03:57:40ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-01-0120358110.3390/ijms20030581ijms20030581High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling PathwayHyuk Moon0Kyungjoo Cho1Sunyeong Shin2Do Young Kim3Kwang-Hyub Han4Simon Weonsang Ro5Yonsei Liver Center, Yonsei University College of Medicine, Seoul 03722, KoreaYonsei Liver Center, Yonsei University College of Medicine, Seoul 03722, KoreaYonsei Liver Center, Yonsei University College of Medicine, Seoul 03722, KoreaYonsei Liver Center, Yonsei University College of Medicine, Seoul 03722, KoreaYonsei Liver Center, Yonsei University College of Medicine, Seoul 03722, KoreaYonsei Liver Center, Yonsei University College of Medicine, Seoul 03722, KoreaLiver cancer is the fourth leading cause of cancer-related death globally, accounting for approximately 800,000 deaths annually. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, making up about 80% of cases. Liver fibrosis and its end-stage disease, cirrhosis, are major risk factors for HCC. A fibrotic liver typically shows persistent hepatocyte death and compensatory regeneration, chronic inflammation, and an increase in reactive oxygen species, which collaboratively create a tumor-promoting microenvironment via inducing genetic alterations and chromosomal instability, and activating various oncogenic molecular signaling pathways. In this article, we review recent advances in fields of liver fibrosis and carcinogenesis, and consider several molecular signaling pathways that promote hepato-carcinogenesis under the microenvironment of liver fibrosis. In particular, we pay attention to emerging roles of the Hippo-YAP/TAZ signaling pathway in stromal activation, hepatic fibrosis, and liver cancer.https://www.mdpi.com/1422-0067/20/3/581hepatocellular carcinomacirrhosisregenerationinflammationcytokinesgenetic instabilityreactive oxygen species |
| spellingShingle | Hyuk Moon Kyungjoo Cho Sunyeong Shin Do Young Kim Kwang-Hyub Han Simon Weonsang Ro High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling Pathway International Journal of Molecular Sciences hepatocellular carcinoma cirrhosis regeneration inflammation cytokines genetic instability reactive oxygen species |
| title | High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling Pathway |
| title_full | High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling Pathway |
| title_fullStr | High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling Pathway |
| title_full_unstemmed | High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling Pathway |
| title_short | High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling Pathway |
| title_sort | high risk of hepatocellular carcinoma development in fibrotic liver role of the hippo yap taz signaling pathway |
| topic | hepatocellular carcinoma cirrhosis regeneration inflammation cytokines genetic instability reactive oxygen species |
| url | https://www.mdpi.com/1422-0067/20/3/581 |
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