A New Bistable Switch Model of Alzheimer’s Disease Pathogenesis

A New Bistable Switch Model of Alzheimer’s Disease Pathogenesis

We propose a model to explain the pathogenesis of Alzheimer’s disease (AD) based on the theory that any disease affecting a healthy organism originates from a bistable feedback loop that shifts the system from a physiological to a pathological condition. We focused on the known double inhibitory loo...

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Bibliographic Details
Main Authors: Bruno Burlando, Serena Losacco, Viviana Villa, Ernesto Fedele, Roberta Ricciarelli
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
amyloid-β
BACE1
cellular prion protein
cyclic nucleotides
bistable switch
feedback loop
Online Access:https://www.mdpi.com/1422-0067/23/13/7061

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