Effect of antihypertensive treatment on the long-term outcome of patients discharged after acute ischemic stroke
We aimed to evaluate the effects of the five main classes of antihypertensive agents on the long-term outcome of 313 consecutive patients discharged after acute ischemic stroke (36.4% males, age 78.5 ± 6.3 years). One year after discharge, the functional status [evaluated with the modified Rankin sc...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-04-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2016.1246561 |
| _version_ | 1797681546551885824 |
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| author | Konstantinos Tziomalos Vasilios Giampatzis Stella D. Bouziana Marianna Spanou Stavroula Kostaki Maria Papadopoulou Stella-Maria Angelopoulou Eleni Margariti Christos Savopoulos Apostolos I. Hatzitolios |
| author_facet | Konstantinos Tziomalos Vasilios Giampatzis Stella D. Bouziana Marianna Spanou Stavroula Kostaki Maria Papadopoulou Stella-Maria Angelopoulou Eleni Margariti Christos Savopoulos Apostolos I. Hatzitolios |
| author_sort | Konstantinos Tziomalos |
| collection | DOAJ |
| description | We aimed to evaluate the effects of the five main classes of antihypertensive agents on the long-term outcome of 313 consecutive patients discharged after acute ischemic stroke (36.4% males, age 78.5 ± 6.3 years). One year after discharge, the functional status [evaluated with the modified Rankin scale (mRS)], the occurrence of cardiovascular events, and vital status were recorded. Patients prescribed angiotensin receptor blockers (ARBs) had lower mRS than patients not prescribed ARBs (1.7 ± 2.0 vs. 2.9 ± 2.5, respectively; p = 0.006). The rates of adverse outcome (mRS 2-6) and cardiovascular events did not differ between patients prescribed each one of the major classes of antihypertensive agents and those not prescribed the respective class. Patients who were prescribed ARBs had lower risk of death during follow-up than patients who did not receive ARBs (9.4 and 26.9%, respectively; p < 0.05). In binary logistic regression analysis, the only independent predictor of all-cause mortality during follow-up was the mRS at discharge (relative risk 1.69, 95% confidence interval 1.25–2.28; p < 0.001). In conclusion, in patients discharged after acute ischemic stroke, administration of ARBs appears to have a more beneficial effect on long-term functional outcome and all-cause mortality than treatment with other classes of antihypertensive agents. |
| first_indexed | 2024-03-11T23:46:25Z |
| format | Article |
| id | doaj.art-cbe249b4e0c54af19ad77ffdfd4f708d |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:46:25Z |
| publishDate | 2017-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-cbe249b4e0c54af19ad77ffdfd4f708d2023-09-19T09:24:45ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062017-04-0139324625010.1080/10641963.2016.12465611246561Effect of antihypertensive treatment on the long-term outcome of patients discharged after acute ischemic strokeKonstantinos Tziomalos0Vasilios Giampatzis1Stella D. Bouziana2Marianna Spanou3Stavroula Kostaki4Maria Papadopoulou5Stella-Maria Angelopoulou6Eleni Margariti7Christos Savopoulos8Apostolos I. Hatzitolios9Medical School, Aristotle University of Thessaloniki, AHEPA HospitalMedical School, Aristotle University of Thessaloniki, AHEPA HospitalMedical School, Aristotle University of Thessaloniki, AHEPA HospitalMedical School, Aristotle University of Thessaloniki, AHEPA HospitalMedical School, Aristotle University of Thessaloniki, AHEPA HospitalMedical School, Aristotle University of Thessaloniki, AHEPA HospitalMedical School, Aristotle University of Thessaloniki, AHEPA HospitalMedical School, Aristotle University of Thessaloniki, AHEPA HospitalMedical School, Aristotle University of Thessaloniki, AHEPA HospitalMedical School, Aristotle University of Thessaloniki, AHEPA HospitalWe aimed to evaluate the effects of the five main classes of antihypertensive agents on the long-term outcome of 313 consecutive patients discharged after acute ischemic stroke (36.4% males, age 78.5 ± 6.3 years). One year after discharge, the functional status [evaluated with the modified Rankin scale (mRS)], the occurrence of cardiovascular events, and vital status were recorded. Patients prescribed angiotensin receptor blockers (ARBs) had lower mRS than patients not prescribed ARBs (1.7 ± 2.0 vs. 2.9 ± 2.5, respectively; p = 0.006). The rates of adverse outcome (mRS 2-6) and cardiovascular events did not differ between patients prescribed each one of the major classes of antihypertensive agents and those not prescribed the respective class. Patients who were prescribed ARBs had lower risk of death during follow-up than patients who did not receive ARBs (9.4 and 26.9%, respectively; p < 0.05). In binary logistic regression analysis, the only independent predictor of all-cause mortality during follow-up was the mRS at discharge (relative risk 1.69, 95% confidence interval 1.25–2.28; p < 0.001). In conclusion, in patients discharged after acute ischemic stroke, administration of ARBs appears to have a more beneficial effect on long-term functional outcome and all-cause mortality than treatment with other classes of antihypertensive agents.http://dx.doi.org/10.1080/10641963.2016.1246561angiotensin-converting enzyme inhibitorsangiotensin receptor blockersantihypertensive treatmentcardiovascular morbidityfunctional outcomestroke |
| spellingShingle | Konstantinos Tziomalos Vasilios Giampatzis Stella D. Bouziana Marianna Spanou Stavroula Kostaki Maria Papadopoulou Stella-Maria Angelopoulou Eleni Margariti Christos Savopoulos Apostolos I. Hatzitolios Effect of antihypertensive treatment on the long-term outcome of patients discharged after acute ischemic stroke Clinical and Experimental Hypertension angiotensin-converting enzyme inhibitors angiotensin receptor blockers antihypertensive treatment cardiovascular morbidity functional outcome stroke |
| title | Effect of antihypertensive treatment on the long-term outcome of patients discharged after acute ischemic stroke |
| title_full | Effect of antihypertensive treatment on the long-term outcome of patients discharged after acute ischemic stroke |
| title_fullStr | Effect of antihypertensive treatment on the long-term outcome of patients discharged after acute ischemic stroke |
| title_full_unstemmed | Effect of antihypertensive treatment on the long-term outcome of patients discharged after acute ischemic stroke |
| title_short | Effect of antihypertensive treatment on the long-term outcome of patients discharged after acute ischemic stroke |
| title_sort | effect of antihypertensive treatment on the long term outcome of patients discharged after acute ischemic stroke |
| topic | angiotensin-converting enzyme inhibitors angiotensin receptor blockers antihypertensive treatment cardiovascular morbidity functional outcome stroke |
| url | http://dx.doi.org/10.1080/10641963.2016.1246561 |
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