Re‐salvage focal low‐dose rate brachytherapy for local recurrence of prostate cancer after salvage focal low‐dose rate brachytherapy

Introduction Salvage brachytherapy represents an effective treatment for local recurrence of prostate cancer after prior external beam radiotherapy. However, the optimal therapeutic strategies for local recurrence after salvage brachytherapy have not yet been determined. Case presentation We describ...

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Main Authors: Takahiro Nakamoto, Takashi Yoshida, Toshiko Shiga, Makoto Taguchi, Takao Mishima, Shigenari Kawakita, Takashi Murota, Hidefumi Kinoshita
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:IJU Case Reports
Subjects:
Online Access:https://doi.org/10.1002/iju5.12670
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author Takahiro Nakamoto
Takashi Yoshida
Toshiko Shiga
Makoto Taguchi
Takao Mishima
Shigenari Kawakita
Takashi Murota
Hidefumi Kinoshita
author_facet Takahiro Nakamoto
Takashi Yoshida
Toshiko Shiga
Makoto Taguchi
Takao Mishima
Shigenari Kawakita
Takashi Murota
Hidefumi Kinoshita
author_sort Takahiro Nakamoto
collection DOAJ
description Introduction Salvage brachytherapy represents an effective treatment for local recurrence of prostate cancer after prior external beam radiotherapy. However, the optimal therapeutic strategies for local recurrence after salvage brachytherapy have not yet been determined. Case presentation We describe the case of a 77‐year‐old man who underwent re‐salvage focal low‐dose rate brachytherapy for local recurrence after carbon ion radiotherapy and salvage focal low‐dose rate brachytherapy. We performed re‐salvage focal low‐dose rate brachytherapy for the recurrence with a different type of seed, which resulted in a significant reduction in the prostate‐specific antigen level. During the 35‐month follow‐up after re‐salvage focal low‐dose rate brachytherapy, no recurrence of prostate cancer and no severe radiation‐related toxicities were observed. Conclusion Our patient was successfully treated with re‐salvage focal low‐dose rate brachytherapy for local recurrence after salvage focal low‐dose rate brachytherapy. This treatment strategy might be effective for such patients and is not associated with sexual dysfunction or severe adverse events.
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spelling doaj.art-cbe327073d6946e18f51eed9bbc34ac22024-01-02T09:18:35ZengWileyIJU Case Reports2577-171X2024-01-0171687210.1002/iju5.12670Re‐salvage focal low‐dose rate brachytherapy for local recurrence of prostate cancer after salvage focal low‐dose rate brachytherapyTakahiro Nakamoto0Takashi Yoshida1Toshiko Shiga2Makoto Taguchi3Takao Mishima4Shigenari Kawakita5Takashi Murota6Hidefumi Kinoshita7Department of Urology and Andrology Kansai Medical University Osaka JapanDepartment of Urology and Andrology Kansai Medical University Osaka JapanDepartment of Radiology Kansai Medical University, Medical Center Osaka JapanDepartment of Urology and Andrology Kansai Medical University, Medical Center Osaka JapanDepartment of Urology and Andrology Kansai Medical University, Medical Center Osaka JapanDepartment of Urology and Andrology Kansai Medical University, Medical Center Osaka JapanDepartment of Urology and Andrology Kansai Medical University, Medical Center Osaka JapanDepartment of Urology and Andrology Kansai Medical University Osaka JapanIntroduction Salvage brachytherapy represents an effective treatment for local recurrence of prostate cancer after prior external beam radiotherapy. However, the optimal therapeutic strategies for local recurrence after salvage brachytherapy have not yet been determined. Case presentation We describe the case of a 77‐year‐old man who underwent re‐salvage focal low‐dose rate brachytherapy for local recurrence after carbon ion radiotherapy and salvage focal low‐dose rate brachytherapy. We performed re‐salvage focal low‐dose rate brachytherapy for the recurrence with a different type of seed, which resulted in a significant reduction in the prostate‐specific antigen level. During the 35‐month follow‐up after re‐salvage focal low‐dose rate brachytherapy, no recurrence of prostate cancer and no severe radiation‐related toxicities were observed. Conclusion Our patient was successfully treated with re‐salvage focal low‐dose rate brachytherapy for local recurrence after salvage focal low‐dose rate brachytherapy. This treatment strategy might be effective for such patients and is not associated with sexual dysfunction or severe adverse events.https://doi.org/10.1002/iju5.12670brachytherapylocal recurrencesalvage therapy
spellingShingle Takahiro Nakamoto
Takashi Yoshida
Toshiko Shiga
Makoto Taguchi
Takao Mishima
Shigenari Kawakita
Takashi Murota
Hidefumi Kinoshita
Re‐salvage focal low‐dose rate brachytherapy for local recurrence of prostate cancer after salvage focal low‐dose rate brachytherapy
IJU Case Reports
brachytherapy
local recurrence
salvage therapy
title Re‐salvage focal low‐dose rate brachytherapy for local recurrence of prostate cancer after salvage focal low‐dose rate brachytherapy
title_full Re‐salvage focal low‐dose rate brachytherapy for local recurrence of prostate cancer after salvage focal low‐dose rate brachytherapy
title_fullStr Re‐salvage focal low‐dose rate brachytherapy for local recurrence of prostate cancer after salvage focal low‐dose rate brachytherapy
title_full_unstemmed Re‐salvage focal low‐dose rate brachytherapy for local recurrence of prostate cancer after salvage focal low‐dose rate brachytherapy
title_short Re‐salvage focal low‐dose rate brachytherapy for local recurrence of prostate cancer after salvage focal low‐dose rate brachytherapy
title_sort re salvage focal low dose rate brachytherapy for local recurrence of prostate cancer after salvage focal low dose rate brachytherapy
topic brachytherapy
local recurrence
salvage therapy
url https://doi.org/10.1002/iju5.12670
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