The clinical significance of allergen-specific IgG4 in allergic diseases

The clinical significance of allergen-specific IgG4 in allergic diseases

IgG4 is a subclass of IgG antibody with a unique molecular feature of (Fragment antigen- binding) Fab-arm exchange, allowing bispecific antigen binding in a mono-valent manner. With low binding affinity to C1q and Fcγreceptors, IgG4 is incapable of forming immune complexes and activating the complem...

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Bibliographic Details
Main Authors:	Lu Qin, Lan-Fang Tang, Lei Cheng, Hui-Ying Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Immunology
Subjects:	IgG4 Fab-arm exchange allergen specific immunotherapy food allergy eosinophilic esophagitis
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1032909/full

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