Effects of portal vein resection and hepatic artery resection on long-term survival in Klatskin tumor: a meta-analysis
Abstract Background Surgical treatment is currently the only way to achieve the clinical cure for Klatskin tumor. However, whether combined vascular resection should be combined during surgeries is still controversial. The aim of this article was to analyze the effect of portal vein resection (PVR)...
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-022-02692-1 |
| _version_ | 1818510692072816640 |
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| author | Yun Song Yujie Zhang Zhijie Zhen Zhaohui Huang |
| author_facet | Yun Song Yujie Zhang Zhijie Zhen Zhaohui Huang |
| author_sort | Yun Song |
| collection | DOAJ |
| description | Abstract Background Surgical treatment is currently the only way to achieve the clinical cure for Klatskin tumor. However, whether combined vascular resection should be combined during surgeries is still controversial. The aim of this article was to analyze the effect of portal vein resection (PVR) and hepatic artery resection (HAR) on the long-term survival after surgery for Klatskin tumor. Methods Articles about Klatskin tumor with PVR and HAR, which were published from 2000 to 2020, were searched using PubMed, Embase, and EBSCO. HR with a 95% CI of overall survival, recurrence-free survival, disease-free survival, 3- and 5-year survival rate, and median survival time were reported to evaluate prognosis. Results A total of 17 articles were included. The total case number of these studies was 3150 (685 in the PVR group, 345 in the HAR group, and 2120 in the control group). Survival analyses showed that both vascular resection types were poor prognostic factors (PVR: HR = 1.50, 95% CI = 1.24–1.81, P < 0.001; HAR: HR = 1.68, 95% CI = 1.26–2.24, P < 0.001; the pooled effect size of the two groups: HR = 1.55, 95% CI = 1.32–1.82, P < 0.001). In general, the analyses of 3- and 5-year survival and median survival time showed that both vascular resection types tended to be poor prognostic factors, but most of recent researches showed that the PVR did not lead to a poor prognosis. Conclusion PVR should be used when necessary to achieve R0 resection of Klatskin tumor and improve the long-term survival of patients. Whether HAR should be performed or not is still need to be evaluated. |
| first_indexed | 2024-12-10T23:23:28Z |
| format | Article |
| id | doaj.art-cbe449b0a35b4990a32f68578c63e1fd |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-10T23:23:28Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-cbe449b0a35b4990a32f68578c63e1fd2022-12-22T01:29:39ZengBMCWorld Journal of Surgical Oncology1477-78192022-07-0120111110.1186/s12957-022-02692-1Effects of portal vein resection and hepatic artery resection on long-term survival in Klatskin tumor: a meta-analysisYun Song0Yujie Zhang1Zhijie Zhen2Zhaohui Huang3Wuxi School of Medicine, Jiangnan UniversityWuxi School of Medicine, Jiangnan UniversityWuxi School of Medicine, Jiangnan UniversityWuxi Cancer Institute, Affiliated Hospital of Jiangnan UniversityAbstract Background Surgical treatment is currently the only way to achieve the clinical cure for Klatskin tumor. However, whether combined vascular resection should be combined during surgeries is still controversial. The aim of this article was to analyze the effect of portal vein resection (PVR) and hepatic artery resection (HAR) on the long-term survival after surgery for Klatskin tumor. Methods Articles about Klatskin tumor with PVR and HAR, which were published from 2000 to 2020, were searched using PubMed, Embase, and EBSCO. HR with a 95% CI of overall survival, recurrence-free survival, disease-free survival, 3- and 5-year survival rate, and median survival time were reported to evaluate prognosis. Results A total of 17 articles were included. The total case number of these studies was 3150 (685 in the PVR group, 345 in the HAR group, and 2120 in the control group). Survival analyses showed that both vascular resection types were poor prognostic factors (PVR: HR = 1.50, 95% CI = 1.24–1.81, P < 0.001; HAR: HR = 1.68, 95% CI = 1.26–2.24, P < 0.001; the pooled effect size of the two groups: HR = 1.55, 95% CI = 1.32–1.82, P < 0.001). In general, the analyses of 3- and 5-year survival and median survival time showed that both vascular resection types tended to be poor prognostic factors, but most of recent researches showed that the PVR did not lead to a poor prognosis. Conclusion PVR should be used when necessary to achieve R0 resection of Klatskin tumor and improve the long-term survival of patients. Whether HAR should be performed or not is still need to be evaluated.https://doi.org/10.1186/s12957-022-02692-1Portal vein resectionHepatic arteryKlatskin tumorSurvivalMeta-analysis |
| spellingShingle | Yun Song Yujie Zhang Zhijie Zhen Zhaohui Huang Effects of portal vein resection and hepatic artery resection on long-term survival in Klatskin tumor: a meta-analysis World Journal of Surgical Oncology Portal vein resection Hepatic artery Klatskin tumor Survival Meta-analysis |
| title | Effects of portal vein resection and hepatic artery resection on long-term survival in Klatskin tumor: a meta-analysis |
| title_full | Effects of portal vein resection and hepatic artery resection on long-term survival in Klatskin tumor: a meta-analysis |
| title_fullStr | Effects of portal vein resection and hepatic artery resection on long-term survival in Klatskin tumor: a meta-analysis |
| title_full_unstemmed | Effects of portal vein resection and hepatic artery resection on long-term survival in Klatskin tumor: a meta-analysis |
| title_short | Effects of portal vein resection and hepatic artery resection on long-term survival in Klatskin tumor: a meta-analysis |
| title_sort | effects of portal vein resection and hepatic artery resection on long term survival in klatskin tumor a meta analysis |
| topic | Portal vein resection Hepatic artery Klatskin tumor Survival Meta-analysis |
| url | https://doi.org/10.1186/s12957-022-02692-1 |
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