GDF‐15 is associated with atherosclerosis in adults with transfusion‐dependent beta‐thalassemia
Abstract Objectives: To study serum growth differentiation factor‐15 (GDF‐15) serum level in β‐thalassemia patients and its relation to carotid intima‐media thickness. Background: Thalassemia is a common genetic disease resulting in decreased beta‐chains, leading to manifested anemia. It may be subs...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-05-01
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| Series: | eJHaem |
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| Online Access: | https://doi.org/10.1002/jha2.415 |
| _version_ | 1797739990744039424 |
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| author | Alaa Efat Rana Wahb Sabry Abd Allah Shoeib Ashraf Abd ElRaof Dawod Mohamad Ahmed Abd ElHafez Essam Ali Abd ElMohsen Aly Elkholy |
| author_facet | Alaa Efat Rana Wahb Sabry Abd Allah Shoeib Ashraf Abd ElRaof Dawod Mohamad Ahmed Abd ElHafez Essam Ali Abd ElMohsen Aly Elkholy |
| author_sort | Alaa Efat |
| collection | DOAJ |
| description | Abstract Objectives: To study serum growth differentiation factor‐15 (GDF‐15) serum level in β‐thalassemia patients and its relation to carotid intima‐media thickness. Background: Thalassemia is a common genetic disease resulting in decreased beta‐chains, leading to manifested anemia. It may be subsequently complicated by iron overload, which induces numerous morbidities and even death. Growth differentiation factor‐15 (GDF‐15) is a strong and independent predictor of mortality and disease progression in patients with atherosclerosis alongside with carotid‐intimal media thickness (CIMT). Patients and methods: This monocentric case‐control study was done on 90 subjects in the period from January 2020 to March 2021. Sixty transfusion‐dependent beta‐thalassemia (TDβT) cases (≥18 years) were selected from the thalassemia clinic of Hematology division at Menoufia University hospitals. We included also 30 sex and age matched healthy as the controls. Routine investigations were done beside. Serum GDF‐15 was measured by ELISA. CIMT was measured by Doppler Ultrasonography. Results: CIMT on both sides was statistically significant higher in cases (median of 0.08 cm) than in the controls (median of 0.04). GDF‐15 was also significantly higher in cases (median of 1839.89 pg/dl) than in controls (median of 256.14 pg/dl). So, we found that GDF‐15 is a predictor of and associated with atherosclerosis in thalassemic adults (OR = 39.198, p value 0.008, 95% CI: 2.576–596.5). Conclusion: GDF‐ 15 is increased in TDβT. CIMT (as a marker of subclinical atherosclerosis) is increased in these patients alongside with GDF‐15, is a predictor, and associated with atherosclerosis in thalassemic adults. |
| first_indexed | 2024-03-12T14:06:06Z |
| format | Article |
| id | doaj.art-cbe44c4dac6b498eb30f277dbd1472d8 |
| institution | Directory Open Access Journal |
| issn | 2688-6146 |
| language | English |
| last_indexed | 2024-03-12T14:06:06Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj.art-cbe44c4dac6b498eb30f277dbd1472d82023-08-21T14:11:09ZengWileyeJHaem2688-61462022-05-013235336110.1002/jha2.415GDF‐15 is associated with atherosclerosis in adults with transfusion‐dependent beta‐thalassemiaAlaa Efat0Rana Wahb1Sabry Abd Allah Shoeib2Ashraf Abd ElRaof Dawod3Mohamad Ahmed Abd ElHafez4Essam Ali Abd ElMohsen5Aly Elkholy6Faculty of Medicine Department of Internal Medicine and Hematology Menoufia University Shebin Al‐Kom Menoufia EgyptFaculty of Medicine Department of Internal Medicine and Hematology Menoufia University Shebin Al‐Kom Menoufia EgyptFaculty of Medicine Department of Internal Medicine and Hematology Menoufia University Shebin Al‐Kom Menoufia EgyptFaculty of Medicine Department of Medical Biochemistry Menoufia University Shebin Al‐Kom Menoufia EgyptFaculty of Medicine Department of Internal Medicine and Hematology Menoufia University Shebin Al‐Kom Menoufia EgyptDepartment of Hematology and Bone Marrow Transplantation, Maadi Military Forces Medical Complex Maadi, Cairo Governorate EgyptFaculty of Medicine Department of Internal Medicine and Hematology Menoufia University Shebin Al‐Kom Menoufia EgyptAbstract Objectives: To study serum growth differentiation factor‐15 (GDF‐15) serum level in β‐thalassemia patients and its relation to carotid intima‐media thickness. Background: Thalassemia is a common genetic disease resulting in decreased beta‐chains, leading to manifested anemia. It may be subsequently complicated by iron overload, which induces numerous morbidities and even death. Growth differentiation factor‐15 (GDF‐15) is a strong and independent predictor of mortality and disease progression in patients with atherosclerosis alongside with carotid‐intimal media thickness (CIMT). Patients and methods: This monocentric case‐control study was done on 90 subjects in the period from January 2020 to March 2021. Sixty transfusion‐dependent beta‐thalassemia (TDβT) cases (≥18 years) were selected from the thalassemia clinic of Hematology division at Menoufia University hospitals. We included also 30 sex and age matched healthy as the controls. Routine investigations were done beside. Serum GDF‐15 was measured by ELISA. CIMT was measured by Doppler Ultrasonography. Results: CIMT on both sides was statistically significant higher in cases (median of 0.08 cm) than in the controls (median of 0.04). GDF‐15 was also significantly higher in cases (median of 1839.89 pg/dl) than in controls (median of 256.14 pg/dl). So, we found that GDF‐15 is a predictor of and associated with atherosclerosis in thalassemic adults (OR = 39.198, p value 0.008, 95% CI: 2.576–596.5). Conclusion: GDF‐ 15 is increased in TDβT. CIMT (as a marker of subclinical atherosclerosis) is increased in these patients alongside with GDF‐15, is a predictor, and associated with atherosclerosis in thalassemic adults.https://doi.org/10.1002/jha2.415CIMTGDF‐15transfusion‐dependent beta‐thalassemic adults |
| spellingShingle | Alaa Efat Rana Wahb Sabry Abd Allah Shoeib Ashraf Abd ElRaof Dawod Mohamad Ahmed Abd ElHafez Essam Ali Abd ElMohsen Aly Elkholy GDF‐15 is associated with atherosclerosis in adults with transfusion‐dependent beta‐thalassemia eJHaem CIMT GDF‐15 transfusion‐dependent beta‐thalassemic adults |
| title | GDF‐15 is associated with atherosclerosis in adults with transfusion‐dependent beta‐thalassemia |
| title_full | GDF‐15 is associated with atherosclerosis in adults with transfusion‐dependent beta‐thalassemia |
| title_fullStr | GDF‐15 is associated with atherosclerosis in adults with transfusion‐dependent beta‐thalassemia |
| title_full_unstemmed | GDF‐15 is associated with atherosclerosis in adults with transfusion‐dependent beta‐thalassemia |
| title_short | GDF‐15 is associated with atherosclerosis in adults with transfusion‐dependent beta‐thalassemia |
| title_sort | gdf 15 is associated with atherosclerosis in adults with transfusion dependent beta thalassemia |
| topic | CIMT GDF‐15 transfusion‐dependent beta‐thalassemic adults |
| url | https://doi.org/10.1002/jha2.415 |
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