Comparison of the Effect of Botulinum Toxin Injection Under Ultrasound Guidance and Oral Propranolol in the Treatment of Moderate to Severe Essential Hand Tremor
Background: Tremor is one of the most common movement disorders affecting the upper limb (proximal and distal), neck, or vocal cords. Primidone and propranolol are the most effective oral medications prescribed for essential tremors. 12 to 66% of those treated with propranolol have complications, an...
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2023-07-01
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| Series: | Neurology Letters |
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| Online Access: | https://www.neurologyletters.com/article_177497_f8ba1647bce766318e8449e5c81490a7.pdf |
| _version_ | 1797630557678469120 |
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| author | Bahador Asadi Sara Hassani Hossein Ghanaati Aryobarzan Rahmatian Mobin Azami Saeed Amiri Gheshlaghi |
| author_facet | Bahador Asadi Sara Hassani Hossein Ghanaati Aryobarzan Rahmatian Mobin Azami Saeed Amiri Gheshlaghi |
| author_sort | Bahador Asadi |
| collection | DOAJ |
| description | Background: Tremor is one of the most common movement disorders affecting the upper limb (proximal and distal), neck, or vocal cords. Primidone and propranolol are the most effective oral medications prescribed for essential tremors. 12 to 66% of those treated with propranolol have complications, and 30% of patients do not respond to oral medications. Methods: In this study, a clinical trial was conducted to compare the effect of botulinum toxin Injection and Oral Propranolol in the Treatment of essential hand Tremor on patients referred to Golestan Hospital's neurology clinic complaining of hand tremor in 2016 and 2017. Eighty essential tremor patients were assigned to the study and divided into two groups, the botulinum toxin group had muscular injection under ultrasound guidance, and the propranolol group received oral propranolol. Patients were evaluated at one-month intervals, weeks 0, 4, 8, and 12. The severity of the tremor was assessed using the TETRAS clinical scale. Another patient evaluation was the RAND SF-36 Quality of Life Questionnaire, which was presented to patients at weeks 0 and 8. Results: Our findings in this study revealed that the intramuscular injection of botulinum toxin is more effective in treating moderate-to-severe Essential Tremor hand than the intake of oral propranolol. Conclusion: Botulinum toxin is recommended for moderate-to-severe cases of essential hand Tremor, especially for patients who fail to bear the treatment course or take several medications that prompt striking drug interference. |
| first_indexed | 2024-03-11T11:08:49Z |
| format | Article |
| id | doaj.art-cbe53d445cac498bbd1266e8ef2bb5ae |
| institution | Directory Open Access Journal |
| issn | 2821-1723 |
| language | English |
| last_indexed | 2024-03-11T11:08:49Z |
| publishDate | 2023-07-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Neurology Letters |
| spelling | doaj.art-cbe53d445cac498bbd1266e8ef2bb5ae2023-11-12T09:10:42ZengIran University of Medical SciencesNeurology Letters2821-17232023-07-0122697710.61186/nl.2.2.69177497Comparison of the Effect of Botulinum Toxin Injection Under Ultrasound Guidance and Oral Propranolol in the Treatment of Moderate to Severe Essential Hand TremorBahador Asadi0Sara Hassani1Hossein Ghanaati2Aryobarzan Rahmatian3Mobin Azami4Saeed Amiri Gheshlaghi5Department of Neurology, AJA University of Medical Sciences, Tehran, IranPennsylvania Diagnostic Radiologist post-doctoral research fellowship, university Perelman school of medicine, Philadelphia, USAAdvanced Diagnostic and Interventional Radiology Research Center(ADIR), Tehran University of Medical Science, Tehran, IranRadiologist professor Interventional radiologist, Tehran university of Medical Science, Tehran, IranStudent Research Committee, Kurdistan University of Medical Sciences, Sanandaj, IranAja university of medical science Tehran Iran, Tehran, IranBackground: Tremor is one of the most common movement disorders affecting the upper limb (proximal and distal), neck, or vocal cords. Primidone and propranolol are the most effective oral medications prescribed for essential tremors. 12 to 66% of those treated with propranolol have complications, and 30% of patients do not respond to oral medications. Methods: In this study, a clinical trial was conducted to compare the effect of botulinum toxin Injection and Oral Propranolol in the Treatment of essential hand Tremor on patients referred to Golestan Hospital's neurology clinic complaining of hand tremor in 2016 and 2017. Eighty essential tremor patients were assigned to the study and divided into two groups, the botulinum toxin group had muscular injection under ultrasound guidance, and the propranolol group received oral propranolol. Patients were evaluated at one-month intervals, weeks 0, 4, 8, and 12. The severity of the tremor was assessed using the TETRAS clinical scale. Another patient evaluation was the RAND SF-36 Quality of Life Questionnaire, which was presented to patients at weeks 0 and 8. Results: Our findings in this study revealed that the intramuscular injection of botulinum toxin is more effective in treating moderate-to-severe Essential Tremor hand than the intake of oral propranolol. Conclusion: Botulinum toxin is recommended for moderate-to-severe cases of essential hand Tremor, especially for patients who fail to bear the treatment course or take several medications that prompt striking drug interference.https://www.neurologyletters.com/article_177497_f8ba1647bce766318e8449e5c81490a7.pdfessential tremorbotulinum toxinpropranololultrasound |
| spellingShingle | Bahador Asadi Sara Hassani Hossein Ghanaati Aryobarzan Rahmatian Mobin Azami Saeed Amiri Gheshlaghi Comparison of the Effect of Botulinum Toxin Injection Under Ultrasound Guidance and Oral Propranolol in the Treatment of Moderate to Severe Essential Hand Tremor Neurology Letters essential tremor botulinum toxin propranolol ultrasound |
| title | Comparison of the Effect of Botulinum Toxin Injection Under Ultrasound Guidance and Oral Propranolol in the Treatment of Moderate to Severe Essential Hand Tremor |
| title_full | Comparison of the Effect of Botulinum Toxin Injection Under Ultrasound Guidance and Oral Propranolol in the Treatment of Moderate to Severe Essential Hand Tremor |
| title_fullStr | Comparison of the Effect of Botulinum Toxin Injection Under Ultrasound Guidance and Oral Propranolol in the Treatment of Moderate to Severe Essential Hand Tremor |
| title_full_unstemmed | Comparison of the Effect of Botulinum Toxin Injection Under Ultrasound Guidance and Oral Propranolol in the Treatment of Moderate to Severe Essential Hand Tremor |
| title_short | Comparison of the Effect of Botulinum Toxin Injection Under Ultrasound Guidance and Oral Propranolol in the Treatment of Moderate to Severe Essential Hand Tremor |
| title_sort | comparison of the effect of botulinum toxin injection under ultrasound guidance and oral propranolol in the treatment of moderate to severe essential hand tremor |
| topic | essential tremor botulinum toxin propranolol ultrasound |
| url | https://www.neurologyletters.com/article_177497_f8ba1647bce766318e8449e5c81490a7.pdf |
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