A Novel Sushi-IL15-PD1 CAR-NK92 Cell Line With Enhanced and PD-L1 Targeted Cytotoxicity Against Pancreatic Cancer Cells

A Novel Sushi-IL15-PD1 CAR-NK92 Cell Line With Enhanced and PD-L1 Targeted Cytotoxicity Against Pancreatic Cancer Cells

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal malignancy with a limited response to current therapies. Novel and effective treatment is urgently needed. Herein, a chimeric antigen receptor (CAR)-NK92 cell line, with an interleukin (IL)-15Rα-sushi/IL-15 complex and a Progr...

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Bibliographic Details
Main Authors: Da-Lai Xu, Yuan-Qing He, Bin Xiao, Yuan Si, Jian Shi, Xue-Ang Liu, Lei Tian, Qian Ren, Ya-Song Wu, Yi Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
pancreatic ductal adenocarcinoma
Chimeric antigen receptor (CAR)
IL-15
IL-15Rα-sushi
programmed cell death ligand 1 (PD-L1)
adoptive immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.726985/full

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