Assessing Tumor-Infiltrating Lymphocytes in Breast Cancer: A Proposal for Combining Immunohistochemistry and Gene Expression Analysis to Refine Scoring

Assessing Tumor-Infiltrating Lymphocytes in Breast Cancer: A Proposal for Combining Immunohistochemistry and Gene Expression Analysis to Refine Scoring

Scoring of tumor-infiltrating lymphocytes (TILs) in breast cancer specimens has gained increasing attention, as TILs have prognostic and predictive value in HER2+ and triple-negative breast cancer. We evaluated the intra- and interrater variability when scoring TILs by visual inspection of hematoxyl...

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Bibliographic Details
Main Authors: Hanne Locy, Stefaan Verhulst, Wilfried Cools, Wim Waelput, Stefanie Brock, Louise Cras, Ann Schiettecatte, Jan Jonckheere, Leo A. van Grunsven, Marian Vanhoeij, Kris Thielemans, Karine Breckpot
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
breast cancer
immunohistochemistry
gene expression profiling
tumor-infiltrating lymphocyte
immunotherapy targets
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.794175/full

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