Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose starvation

Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose starvation

ABSTRACTHuman cytomegalovirus (HCMV) modulates cellular metabolism to support productive infection, and the HCMV UL38 protein drives many aspects of this HCMV-induced metabolic program. However, it remains to be determined whether virally induced metabolic alterations might induce novel therapeutic...

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Bibliographic Details
Main Authors: Matthew H. Raymonda, Irene Rodríguez-Sánchez, Xenia L. Schafer, Leonid Smorodintsev-Schiller, Isaac S. Harris, Joshua Munger
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:mBio
Subjects:
human cytomegalovirus
UL38
metabolism
TSC2
glycolysis
lipogenesis
Online Access:https://journals.asm.org/doi/10.1128/mbio.03031-23

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