Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak
<p>Abstract</p> <p>Chikungunya has resurged in the form of unprecedented explosive epidemic in 2006 after a long gap in India affecting 1.39 million of persons. The disease continued for the next two consecutive years affecting 59,535 and 64,548 persons during 2007 and 2008 respect...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-10-01
|
| Series: | Virology Journal |
| Online Access: | http://www.virologyj.com/content/6/1/172 |
| _version_ | 1828255096804212736 |
|---|---|
| author | Khan Mohasin Parida Manmohan Dash Paban Santhosh SR Rao Putcha VL |
| author_facet | Khan Mohasin Parida Manmohan Dash Paban Santhosh SR Rao Putcha VL |
| author_sort | Khan Mohasin |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Chikungunya has resurged in the form of unprecedented explosive epidemic in 2006 after a long gap in India affecting 1.39 million of persons. The disease continued for the next two consecutive years affecting 59,535 and 64,548 persons during 2007 and 2008 respectively. The 2008 outbreak being the second largest among these three years the information regarding the etiology and the mutations involved are useful for further control measures. Among the 2008 outbreaks the Coastal Karnataka accounts for the 46,510 persons. An in-depth investigation of Chikungunya epidemic of Coastal Karnataka, India, 2008 by serology, virus isolation, RT-PCR and genome sequencing revealed the presence and continued circulation of A226V mutant Chikungunya virus. The appearance of this mutant virus was found to be associated with higher prevalence of vector <it>Aedes albopictus </it>and the geographical proximity of coastal Karnataka with the adjoining Kerala state. This is the first report regarding the appearance of this mutation in Karnataka state of India. The present study identified the presence and association of A226V mutant virus with Chikungunya outbreak in India during 2008.</p> |
| first_indexed | 2024-04-13T02:09:35Z |
| format | Article |
| id | doaj.art-cbeacd8cff594d2dabfcbefcabd4c1b9 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-04-13T02:09:35Z |
| publishDate | 2009-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-cbeacd8cff594d2dabfcbefcabd4c1b92022-12-22T03:07:21ZengBMCVirology Journal1743-422X2009-10-016117210.1186/1743-422X-6-172Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreakKhan MohasinParida ManmohanDash PabanSanthosh SRRao Putcha VL<p>Abstract</p> <p>Chikungunya has resurged in the form of unprecedented explosive epidemic in 2006 after a long gap in India affecting 1.39 million of persons. The disease continued for the next two consecutive years affecting 59,535 and 64,548 persons during 2007 and 2008 respectively. The 2008 outbreak being the second largest among these three years the information regarding the etiology and the mutations involved are useful for further control measures. Among the 2008 outbreaks the Coastal Karnataka accounts for the 46,510 persons. An in-depth investigation of Chikungunya epidemic of Coastal Karnataka, India, 2008 by serology, virus isolation, RT-PCR and genome sequencing revealed the presence and continued circulation of A226V mutant Chikungunya virus. The appearance of this mutant virus was found to be associated with higher prevalence of vector <it>Aedes albopictus </it>and the geographical proximity of coastal Karnataka with the adjoining Kerala state. This is the first report regarding the appearance of this mutation in Karnataka state of India. The present study identified the presence and association of A226V mutant virus with Chikungunya outbreak in India during 2008.</p>http://www.virologyj.com/content/6/1/172 |
| spellingShingle | Khan Mohasin Parida Manmohan Dash Paban Santhosh SR Rao Putcha VL Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak Virology Journal |
| title | Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak |
| title_full | Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak |
| title_fullStr | Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak |
| title_full_unstemmed | Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak |
| title_short | Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak |
| title_sort | appearance of e1 a226v mutant chikungunya virus in coastal karnataka india during 2008 outbreak |
| url | http://www.virologyj.com/content/6/1/172 |
| work_keys_str_mv | AT khanmohasin appearanceofe1a226vmutantchikungunyavirusincoastalkarnatakaindiaduring2008outbreak AT paridamanmohan appearanceofe1a226vmutantchikungunyavirusincoastalkarnatakaindiaduring2008outbreak AT dashpaban appearanceofe1a226vmutantchikungunyavirusincoastalkarnatakaindiaduring2008outbreak AT santhoshsr appearanceofe1a226vmutantchikungunyavirusincoastalkarnatakaindiaduring2008outbreak AT raoputchavl appearanceofe1a226vmutantchikungunyavirusincoastalkarnatakaindiaduring2008outbreak |