MFG-E8 and HMGB1 Are Involved in the Mechanism Underlying Alcohol-Induced Impairment of Macrophage Efferocytosis

MFG-E8 and HMGB1 Are Involved in the Mechanism Underlying Alcohol-Induced Impairment of Macrophage Efferocytosis

Abstract Efferocytosis is a unique phagocytic process for macrophages to remove apoptotic cells in inflammatory loci. This event is maintained by milk fat globule-EGF factor 8 (MFG-E8), but attenuated by high mobility group box 1 (HMGB1). Alcohol abuse causes injury and inflammation in multiple tiss...

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Bibliographic Details
Main Authors: Xiao Wang, Heng-Fu Bu, Wei Zhong, Akihiro Asai, Zhanxiang Zhou, Xiao-Di Tan
Format: Article
Language:English
Published: BMC 2013-03-01
Series:Molecular Medicine
Subjects:
High Mobility Group Box (HMGB1)
Macrophage Efferocytosis
Acute Alcohol Exposure
Chronic Alcohol Treatment
HMGB1 Levels
Online Access:https://doi.org/10.2119/molmed.2012.00260

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