Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study
Introduction: We explored the association between clinical outcomes and the cleavage rate of day-3 cleavage slow-growing embryos after overnight culture. Methods: The data collected from 303 frozen embryo transfer (FET) cycles with 606 4-cell or 5-cell embryos cultured overnight (18–22 h) after thaw...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/15/4417 |
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| author | Lan Geng Xinran Lin Rang Liu Jiahui Wu Yongsheng Luo Hongmei Sun Zhenhui Hou Qiuju Zhang Chang Xu Xiao Li Canhui Cao Tianren Wang Xi Xia |
| author_facet | Lan Geng Xinran Lin Rang Liu Jiahui Wu Yongsheng Luo Hongmei Sun Zhenhui Hou Qiuju Zhang Chang Xu Xiao Li Canhui Cao Tianren Wang Xi Xia |
| author_sort | Lan Geng |
| collection | DOAJ |
| description | Introduction: We explored the association between clinical outcomes and the cleavage rate of day-3 cleavage slow-growing embryos after overnight culture. Methods: The data collected from 303 frozen embryo transfer (FET) cycles with 606 4-cell or 5-cell embryos cultured overnight (18–22 h) after thawing were analyzed. Based on the growth rate after the overnight culture, the embryos were divided into three groups: no embryo reaching eight cells (Group I), either one of the two embryos reaching eight cells (Group II), and both two embryos reaching eight cells or more (Group III). A statistical analysis of the different clinical outcomes from the three groups was performed. Results: Biochemical pregnancy rate (OR 3.22; <i>p</i> = 0.001), implantation rate (OR 2.44; <i>p</i> = 0.002), clinical pregnancy rate (OR 3.04; <i>p</i> = 0.001), ongoing pregnancy rate (OR 3.14; <i>p</i> = 0.001), and live birth rate (OR 2.78; <i>p</i> = 0.004) were significantly higher in Group III as compared to Group I. Group II had a significantly higher biochemical pregnancy rate (OR 2.02; <i>p</i> = 0.013) and implantation rate (OR 1.77; <i>p</i> = 0.019) than Group I. Conclusions: The capability of day-3 cleavage slow-growing embryos to reach eight cells, especially that of two embryos reaching eight cells by overnight culture, appear to result in a better pregnancy outcome. |
| first_indexed | 2024-03-09T05:18:33Z |
| format | Article |
| id | doaj.art-cbee2129a5244fa9b01ffe9e9f597df5 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T05:18:33Z |
| publishDate | 2022-07-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-cbee2129a5244fa9b01ffe9e9f597df52023-12-03T12:43:06ZengMDPI AGJournal of Clinical Medicine2077-03832022-07-011115441710.3390/jcm11154417Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective StudyLan Geng0Xinran Lin1Rang Liu2Jiahui Wu3Yongsheng Luo4Hongmei Sun5Zhenhui Hou6Qiuju Zhang7Chang Xu8Xiao Li9Canhui Cao10Tianren Wang11Xi Xia12Center for Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518000, ChinaMedical College, Shantou University Medical College, Shantou 515063, ChinaCenter for Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518000, ChinaDepartment of Gynecology, Shenzhen Maternity & Child Healthcare Hospital, Shenzhen 518000, ChinaQuality Control Department, The Second People’s Hospital of Futian District, Shenzhen 518000, ChinaCenter for Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518000, ChinaCenter for Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518000, ChinaCenter for Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518000, ChinaCenter for Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518000, ChinaShenzhen Health Capacity Building and Continuing Education Center, Shenzhen 518000, ChinaCenter for Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518000, ChinaCenter for Reproductive Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518000, ChinaCenter for Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518000, ChinaIntroduction: We explored the association between clinical outcomes and the cleavage rate of day-3 cleavage slow-growing embryos after overnight culture. Methods: The data collected from 303 frozen embryo transfer (FET) cycles with 606 4-cell or 5-cell embryos cultured overnight (18–22 h) after thawing were analyzed. Based on the growth rate after the overnight culture, the embryos were divided into three groups: no embryo reaching eight cells (Group I), either one of the two embryos reaching eight cells (Group II), and both two embryos reaching eight cells or more (Group III). A statistical analysis of the different clinical outcomes from the three groups was performed. Results: Biochemical pregnancy rate (OR 3.22; <i>p</i> = 0.001), implantation rate (OR 2.44; <i>p</i> = 0.002), clinical pregnancy rate (OR 3.04; <i>p</i> = 0.001), ongoing pregnancy rate (OR 3.14; <i>p</i> = 0.001), and live birth rate (OR 2.78; <i>p</i> = 0.004) were significantly higher in Group III as compared to Group I. Group II had a significantly higher biochemical pregnancy rate (OR 2.02; <i>p</i> = 0.013) and implantation rate (OR 1.77; <i>p</i> = 0.019) than Group I. Conclusions: The capability of day-3 cleavage slow-growing embryos to reach eight cells, especially that of two embryos reaching eight cells by overnight culture, appear to result in a better pregnancy outcome.https://www.mdpi.com/2077-0383/11/15/4417slow-growing embryoovernight culturefrozen embryo transfercleavage rate |
| spellingShingle | Lan Geng Xinran Lin Rang Liu Jiahui Wu Yongsheng Luo Hongmei Sun Zhenhui Hou Qiuju Zhang Chang Xu Xiao Li Canhui Cao Tianren Wang Xi Xia Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study Journal of Clinical Medicine slow-growing embryo overnight culture frozen embryo transfer cleavage rate |
| title | Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study |
| title_full | Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study |
| title_fullStr | Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study |
| title_full_unstemmed | Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study |
| title_short | Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study |
| title_sort | clinical outcome of day 3 cleavage slow growing embryos at different cleavage rates after overnight culture a cohort retrospective study |
| topic | slow-growing embryo overnight culture frozen embryo transfer cleavage rate |
| url | https://www.mdpi.com/2077-0383/11/15/4417 |
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