Synthesis and Biological Evaluation of Novel Pyrane Glycosides
A series of novel (5R)-5-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-3-(4-fluorophenyl)-2,6-diphenyl-3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d]thiazoles 11a–g and (5R)-5-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Slovenian Chemical Society
2020-12-01
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| Series: | Acta Chimica Slovenica |
| Subjects: | |
| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/5752 |
| _version_ | 1818363900464201728 |
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| author | Avula Sri Nivas Malladi Sun Itha Sriramoju Sha Mili |
| author_facet | Avula Sri Nivas Malladi Sun Itha Sriramoju Sha Mili |
| author_sort | Avula Sri Nivas |
| collection | DOAJ |
| description | A series of novel (5R)-5-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-3-(4-fluorophenyl)-2,6-diphenyl-3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d]thiazoles 11a–g and (5R)-5-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-3-(4-fluorophenyl)-6-phenyl-3,3a,5,6-tetrahydroisoxazolo[3,4-d]thiazoles 12a–g were synthesized by the reaction of chalcone derivatives of (R,Z)-2-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-5-(4-fluorobenzylidene)-3-phenylthiazolidin-4-ones 10a–g with phenylhydrazine and hydroxylamine hydrochloride. The chemical structures of newly synthesized compounds were elucidated by IR, NMR, MS and elemental analysis. The compounds 11a–g and 12a–g were evaluated for their antibacterial activity and antifungal activity. |
| first_indexed | 2024-12-13T21:55:49Z |
| format | Article |
| id | doaj.art-cbef21ecf66e40a1a83cd30583675a18 |
| institution | Directory Open Access Journal |
| issn | 1318-0207 1580-3155 |
| language | English |
| last_indexed | 2024-12-13T21:55:49Z |
| publishDate | 2020-12-01 |
| publisher | Slovenian Chemical Society |
| record_format | Article |
| series | Acta Chimica Slovenica |
| spelling | doaj.art-cbef21ecf66e40a1a83cd30583675a182022-12-21T23:30:08ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552020-12-016741061107110.17344/acsi.2019.5752897Synthesis and Biological Evaluation of Novel Pyrane GlycosidesAvula Sri Nivas0Malladi Sun Itha1Sriramoju Sha Mili2Lec in chemistryHead dept of chemistryLecturerA series of novel (5R)-5-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-3-(4-fluorophenyl)-2,6-diphenyl-3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d]thiazoles 11a–g and (5R)-5-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-3-(4-fluorophenyl)-6-phenyl-3,3a,5,6-tetrahydroisoxazolo[3,4-d]thiazoles 12a–g were synthesized by the reaction of chalcone derivatives of (R,Z)-2-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-5-(4-fluorobenzylidene)-3-phenylthiazolidin-4-ones 10a–g with phenylhydrazine and hydroxylamine hydrochloride. The chemical structures of newly synthesized compounds were elucidated by IR, NMR, MS and elemental analysis. The compounds 11a–g and 12a–g were evaluated for their antibacterial activity and antifungal activity.https://journals.matheo.si/index.php/ACSi/article/view/5752glycosidesclick reactioncyclisationthiazolo pyrazolesthiazolo isoxazoles antimicrobial activity |
| spellingShingle | Avula Sri Nivas Malladi Sun Itha Sriramoju Sha Mili Synthesis and Biological Evaluation of Novel Pyrane Glycosides Acta Chimica Slovenica glycosides click reaction cyclisation thiazolo pyrazoles thiazolo isoxazoles antimicrobial activity |
| title | Synthesis and Biological Evaluation of Novel Pyrane Glycosides |
| title_full | Synthesis and Biological Evaluation of Novel Pyrane Glycosides |
| title_fullStr | Synthesis and Biological Evaluation of Novel Pyrane Glycosides |
| title_full_unstemmed | Synthesis and Biological Evaluation of Novel Pyrane Glycosides |
| title_short | Synthesis and Biological Evaluation of Novel Pyrane Glycosides |
| title_sort | synthesis and biological evaluation of novel pyrane glycosides |
| topic | glycosides click reaction cyclisation thiazolo pyrazoles thiazolo isoxazoles antimicrobial activity |
| url | https://journals.matheo.si/index.php/ACSi/article/view/5752 |
| work_keys_str_mv | AT avulasrinivas synthesisandbiologicalevaluationofnovelpyraneglycosides AT malladisunitha synthesisandbiologicalevaluationofnovelpyraneglycosides AT sriramojushamili synthesisandbiologicalevaluationofnovelpyraneglycosides |