Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children

Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children

Despite being key drivers of protective antibodies against malaria, little is known regarding the host and parasite factors that influence CD4 T-follicular helper cell and antibody development. Authors utilise samples from a study of children living in an area of high malaria transmission in Uganda,...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Jo-Anne Chan, Jessica R. Loughland, Lauren de la Parte, Satomi Okano, Isaac Ssewanyana, Mayimuna Nalubega, Felistas Nankya, Kenneth Musinguzi, John Rek, Emmanuel Arinaitwe, Peta Tipping, Peter Bourke, Dean Andrew, Nicholas Dooley, Arya SheelaNair, Bruce D. Wines, P. Mark Hogarth, James G. Beeson, Bryan Greenhouse, Grant Dorsey, Moses Kamya, Gunter Hartel, Gabriela Minigo, Margaret Feeney, Prasanna Jagannathan, Michelle J. Boyle
التنسيق: مقال
اللغة:English
منشور في: Nature Portfolio 2022-07-01
سلاسل:Nature Communications
الوصول للمادة أونلاين:https://doi.org/10.1038/s41467-022-31880-6
الوصف
الملخص:Despite being key drivers of protective antibodies against malaria, little is known regarding the host and parasite factors that influence CD4 T-follicular helper cell and antibody development. Authors utilise samples from a study of children living in an area of high malaria transmission in Uganda, to characterize Tfh cells and functional antibodies to multiple parasites stages.
تدمد:2041-1723

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