Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children

Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children

Despite being key drivers of protective antibodies against malaria, little is known regarding the host and parasite factors that influence CD4 T-follicular helper cell and antibody development. Authors utilise samples from a study of children living in an area of high malaria transmission in Uganda,...

Bibliografiset tiedot
Päätekijät:	Jo-Anne Chan, Jessica R. Loughland, Lauren de la Parte, Satomi Okano, Isaac Ssewanyana, Mayimuna Nalubega, Felistas Nankya, Kenneth Musinguzi, John Rek, Emmanuel Arinaitwe, Peta Tipping, Peter Bourke, Dean Andrew, Nicholas Dooley, Arya SheelaNair, Bruce D. Wines, P. Mark Hogarth, James G. Beeson, Bryan Greenhouse, Grant Dorsey, Moses Kamya, Gunter Hartel, Gabriela Minigo, Margaret Feeney, Prasanna Jagannathan, Michelle J. Boyle
Aineistotyyppi:	Artikkeli
Kieli:	English
Julkaistu:	Nature Portfolio 2022-07-01
Sarja:	Nature Communications
Linkit:	https://doi.org/10.1038/s41467-022-31880-6

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Tekijä: Michelle J Boyle, et al.
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Tekijä: Prasanna Jagannathan, et al.
Julkaistu: (2014-01-01)

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Tekijä: Richard T Sullivan, et al.
Julkaistu: (2015-05-01)

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Tekijä: Lila Farrington, et al.
Julkaistu: (2017-12-01)

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Tekijä: Isabel Rodriguez-Barraquer, et al.
Julkaistu: (2018-07-01)

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Tekijä: Adam S. Kirosingh, et al.
Julkaistu: (2023-09-01)

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Tekijä: Lusajo Mwakibete, et al.
Julkaistu: (2023-01-01)

Regulators of Tfh cell differentiation
Tekijä: Gajendra Motiram Jogdand, et al.
Julkaistu: (2016-11-01)

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Tekijä: Pauline Beurier, et al.
Julkaistu: (2021-08-01)

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Tekijä: Jiwei Zhao, et al.
Julkaistu: (2018-10-01)

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Tekijä: Oyong, DA, et al.
Julkaistu: (2021)

Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial.
Tekijä: Prasanna Jagannathan, et al.
Julkaistu: (2018-07-01)

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Tekijä: Shereen Katrak, et al.
Julkaistu: (2018-02-01)

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Tekijä: Ana Coraglia, et al.
Julkaistu: (2016-01-01)

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Tekijä: Mary Prahl, et al.
Julkaistu: (2016-10-01)

Functions of Tfh Cells in Common Variable Immunodeficiency
Tekijä: Corentin Le Saos-Patrinos, et al.
Julkaistu: (2020-01-01)

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Tekijä: Raphael A Reyes, et al.
Julkaistu: (2024-10-01)

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Tekijä: Elliot T Byford, et al.
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Transcriptional regulation of Tfh dynamics and the formation of immunological synapses
Tekijä: Ye-Ji Kim, et al.
Julkaistu: (2024-06-01)

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Tekijä: Marie Donzel, et al.
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Tekijä: Xia Zhao, et al.
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Tekijä: Chunmei Ye, et al.
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Tekijä: Ji-wen Fan, et al.
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Tekijä: Jean C. Digitale, et al.
Julkaistu: (2021-03-01)

Measures of malaria transmission, infection, and disease in an area bordering two districts with and without sustained indoor residual spraying of insecticide in Uganda.
Tekijä: Joaniter I Nankabirwa, et al.
Julkaistu: (2022-01-01)

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Tekijä: Papa, I, et al.
Julkaistu: (2017)

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Tekijä: Muhammad Yaqub, et al.
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Tekijä: James L. Quinn, et al.
Julkaistu: (2018-02-01)

Association between Tfh and PGA in children with Henoch–Schönlein purpura
Tekijä: Meihua Miao, et al.
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Tekijä: Yuwen Chen, et al.
Julkaistu: (2021-03-01)

Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda
Tekijä: Jagannathan Prasanna, et al.
Julkaistu: (2012-12-01)

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Julkaistu: (2021-03-01)

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Plasmodium falciparum activates CD16+ dendritic cells to produce TNF and IL-10 in subpatent malaria
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