Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children

Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children

Despite being key drivers of protective antibodies against malaria, little is known regarding the host and parasite factors that influence CD4 T-follicular helper cell and antibody development. Authors utilise samples from a study of children living in an area of high malaria transmission in Uganda,...

書目詳細資料
Main Authors:	Jo-Anne Chan, Jessica R. Loughland, Lauren de la Parte, Satomi Okano, Isaac Ssewanyana, Mayimuna Nalubega, Felistas Nankya, Kenneth Musinguzi, John Rek, Emmanuel Arinaitwe, Peta Tipping, Peter Bourke, Dean Andrew, Nicholas Dooley, Arya SheelaNair, Bruce D. Wines, P. Mark Hogarth, James G. Beeson, Bryan Greenhouse, Grant Dorsey, Moses Kamya, Gunter Hartel, Gabriela Minigo, Margaret Feeney, Prasanna Jagannathan, Michelle J. Boyle
格式:	Article
語言:	English
出版:	Nature Portfolio 2022-07-01
叢編:	Nature Communications
在線閱讀:	https://doi.org/10.1038/s41467-022-31880-6

相似書籍

Opsonized antigen activates Vδ2+ T cells via CD16/FCγRIIIa in individuals with chronic malaria exposure.
由: Lila A Farrington, et al.
出版: (2020-10-01)

Exposure to pesticides in utero impacts the fetal immune system and response to vaccination in infancy
由: Mary Prahl, et al.
出版: (2021-01-01)

Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria.
由: Michelle J Boyle, et al.
出版: (2015-07-01)

The Development of Plasmodium falciparum-Specific IL10 CD4 T Cells and Protection from Malaria in Children in an Area of High Malaria Transmission
由: Michelle J. Boyle, et al.
出版: (2017-10-01)

Impact of a Rapid Decline in Malaria Transmission on Antimalarial IgG Subclasses and Avidity
由: Isaac Ssewanyana, et al.
出版: (2021-01-01)

IFNγ/IL-10 co-producing cells dominate the CD4 response to malaria in highly exposed children.
由: Prasanna Jagannathan, et al.
出版: (2014-01-01)

FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure.
由: Richard T Sullivan, et al.
出版: (2015-05-01)

Both inflammatory and regulatory cytokine responses to malaria are blunted with increasing age in highly exposed children
由: Lila Farrington, et al.
出版: (2017-12-01)

Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure
由: Isabel Rodriguez-Barraquer, et al.
出版: (2018-07-01)

Natural killer cell antibody‐dependent cellular cytotoxicity to Plasmodium falciparum is impacted by cellular phenotypes, erythrocyte polymorphisms, parasite diversity and intensity of transmission
由: Stephen Tukwasibwe, et al.
出版: (2024-01-01)

Malaria-specific Type 1 regulatory T cells are more abundant in first pregnancies and associated with placental malariaResearch in context
由: Adam S. Kirosingh, et al.
出版: (2023-09-01)

Metagenomic next-generation sequencing to characterize potential etiologies of non-malarial fever in a cohort living in a high malaria burden area of Uganda.
由: Lusajo Mwakibete, et al.
出版: (2023-01-01)

Regulators of Tfh cell differentiation
由: Gajendra Motiram Jogdand, et al.
出版: (2016-11-01)

TFH cells in systemic sclerosis
由: Pauline Beurier, et al.
出版: (2021-08-01)

Increased circulating Tfh17 and PD-1+Tfh cells are associated with autoantibodies in Hashimoto’s thyroiditis
由: Jiwei Zhao, et al.
出版: (2018-10-01)

Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children
由: Oyong, DA, et al.
出版: (2021)

Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial.
由: Prasanna Jagannathan, et al.
出版: (2018-07-01)

Clinical consequences of submicroscopic malaria parasitaemia in Uganda
由: Shereen Katrak, et al.
出版: (2018-02-01)

Common Variable Immunodeficiency and Circulating TFH
由: Ana Coraglia, et al.
出版: (2016-01-01)

Timing of in utero malaria exposure influences fetal CD4 T cell regulatory versus effector differentiation
由: Mary Prahl, et al.
出版: (2016-10-01)

Functions of Tfh Cells in Common Variable Immunodeficiency
由: Corentin Le Saos-Patrinos, et al.
出版: (2020-01-01)

Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens.
由: Raphael A Reyes, et al.
出版: (2024-10-01)

Circulating Tfh1 (cTfh1) cell numbers and PD1 expression are elevated in low-grade B-cell non-Hodgkin's lymphoma and cTfh gene expression is perturbed in marginal zone lymphoma.
由: Elliot T Byford, et al.
出版: (2018-01-01)

Transcriptional regulation of Tfh dynamics and the formation of immunological synapses
由: Ye-Ji Kim, et al.
出版: (2024-06-01)

Deciphering the spectrum of cutaneous lymphomas expressing TFH markers
由: Marie Donzel, et al.
出版: (2023-04-01)

Triptolide regulates the balance of Tfr/Tfh in lupus mice
由: Xia Zhao, et al.
出版: (2023-07-01)

Role of Tfh17 cells in patients with multiple myeloma
由: Chunmei Ye, et al.
出版: (2022-12-01)

The Ratio of CD226 and TIGIT Expression in Tfh and PD-1+ICOS+Tfh Cells Are Potential Biomarkers for Chronic Antibody-Mediated Rejection in Kidney Transplantation
由: Ji-wen Fan, et al.
出版: (2022-01-01)

HLA Alleles B*53:01 and C*06:02 Are Associated With Higher Risk of P. falciparum Parasitemia in a Cohort in Uganda
由: Jean C. Digitale, et al.
出版: (2021-03-01)

Measures of malaria transmission, infection, and disease in an area bordering two districts with and without sustained indoor residual spraying of insecticide in Uganda.
由: Joaniter I Nankabirwa, et al.
出版: (2022-01-01)

TFH-derived dopamine accelerates productive synapses in germinal centres
由: Papa, I, et al.
出版: (2017)

Tfh cells potential dual role in cancer: A perspective
由: Muhammad Yaqub, et al.
出版: (2024-10-01)

Role of TFH Cells in Promoting T Helper 17-Induced Neuroinflammation
由: James L. Quinn, et al.
出版: (2018-02-01)

Association between Tfh and PGA in children with Henoch–Schönlein purpura
由: Meihua Miao, et al.
出版: (2021-07-01)

Platelet desialylation and TFH cells–the novel pathway of immune thrombocytopenia
由: Yuwen Chen, et al.
出版: (2021-03-01)

Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda
由: Jagannathan Prasanna, et al.
出版: (2012-12-01)

91074 Identification of monoclonal antibodies with broad reactivity against the malaria parasite variant surface antigen responsible for severe malaria
由: Raphael Reyes, et al.
出版: (2021-03-01)

Estimating the optimal interval between rounds of indoor residual spraying of insecticide using malaria incidence data from cohort studies.
由: Levicatus Mugenyi, et al.
出版: (2020-01-01)

Staphylococcus aureus Internalized by Skin Keratinocytes Evade Antibiotic Killing
由: Arwa Al Kindi, et al.
出版: (2019-09-01)

Plasmodium falciparum activates CD16+ dendritic cells to produce TNF and IL-10 in subpatent malaria
由: Loughland, JR, et al.
出版: (2018)