Preservative effects of Aspirin on Human Hemoglobin glycation in Diabetic Condition
Abstract Background & aim: Diabetes is a common disease which is characterized by hyperglycemia and the increase of protein glycation. The aim of this study was to investigate the effect of aspirin-induced damage in human hemoglobin in diabetic glycation. Materials & Methods: In this study,...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Yasuj University Of Medical Sciences
2013-10-01
|
| Series: | Armaghane Danesh Bimonthly Journal |
| Subjects: | |
| Online Access: | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-117&slc_lang=en&sid=1 |
| _version_ | 1811205256613199872 |
|---|---|
| author | A Divsalar J Behroozi AA Saboury NN Poursasan |
| author_facet | A Divsalar J Behroozi AA Saboury NN Poursasan |
| author_sort | A Divsalar |
| collection | DOAJ |
| description | Abstract
Background & aim: Diabetes is a common disease which is characterized by hyperglycemia and the increase of protein glycation. The aim of this study was to investigate the effect of aspirin-induced damage in human hemoglobin in diabetic glycation.
Materials & Methods: In this study, hemoglobin extracted from the blood of healthy individuals was incubated in the presence and absence of glucose and aspirin for 5 weeks. The rate of haem glycotation was determined in different conditions by studding products of Heam degradation, sort-band shifting and febrile state. Data were analyzed using One-Way analysis of Variance and Tukey’s test.
Results: In the presence of aspirin, the amount of glycation reduced 50%. Furthermore, studies using band-shift sorting and febrile status indicated significant reduce in the amount of protein glycation in the presence of Aspirin.
Conclusions: Aspirin reduces extent of glycation when hemoglobin is incubated in the presence of glucose. Likely, aspirin exerts its effect by acetylating amine groups in proteins.
Key words: Diabetes, Glycation, Hemoglobin, Aspirin |
| first_indexed | 2024-04-12T03:27:36Z |
| format | Article |
| id | doaj.art-cbf27869e2f948c6b0a20c3409bd7d4a |
| institution | Directory Open Access Journal |
| issn | 1728-6506 1728-6514 |
| language | fas |
| last_indexed | 2024-04-12T03:27:36Z |
| publishDate | 2013-10-01 |
| publisher | Yasuj University Of Medical Sciences |
| record_format | Article |
| series | Armaghane Danesh Bimonthly Journal |
| spelling | doaj.art-cbf27869e2f948c6b0a20c3409bd7d4a2022-12-22T03:49:37ZfasYasuj University Of Medical SciencesArmaghane Danesh Bimonthly Journal1728-65061728-65142013-10-01186453462Preservative effects of Aspirin on Human Hemoglobin glycation in Diabetic ConditionA Divsalar0J Behroozi1AA Saboury2NN Poursasan3 Abstract Background & aim: Diabetes is a common disease which is characterized by hyperglycemia and the increase of protein glycation. The aim of this study was to investigate the effect of aspirin-induced damage in human hemoglobin in diabetic glycation. Materials & Methods: In this study, hemoglobin extracted from the blood of healthy individuals was incubated in the presence and absence of glucose and aspirin for 5 weeks. The rate of haem glycotation was determined in different conditions by studding products of Heam degradation, sort-band shifting and febrile state. Data were analyzed using One-Way analysis of Variance and Tukey’s test. Results: In the presence of aspirin, the amount of glycation reduced 50%. Furthermore, studies using band-shift sorting and febrile status indicated significant reduce in the amount of protein glycation in the presence of Aspirin. Conclusions: Aspirin reduces extent of glycation when hemoglobin is incubated in the presence of glucose. Likely, aspirin exerts its effect by acetylating amine groups in proteins. Key words: Diabetes, Glycation, Hemoglobin, Aspirinhttp://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-117&slc_lang=en&sid=1Key words: Diabetes Glycation Hemoglobin Aspirin |
| spellingShingle | A Divsalar J Behroozi AA Saboury NN Poursasan Preservative effects of Aspirin on Human Hemoglobin glycation in Diabetic Condition Armaghane Danesh Bimonthly Journal Key words: Diabetes Glycation Hemoglobin Aspirin |
| title | Preservative effects of Aspirin on Human Hemoglobin glycation in Diabetic Condition |
| title_full | Preservative effects of Aspirin on Human Hemoglobin glycation in Diabetic Condition |
| title_fullStr | Preservative effects of Aspirin on Human Hemoglobin glycation in Diabetic Condition |
| title_full_unstemmed | Preservative effects of Aspirin on Human Hemoglobin glycation in Diabetic Condition |
| title_short | Preservative effects of Aspirin on Human Hemoglobin glycation in Diabetic Condition |
| title_sort | preservative effects of aspirin on human hemoglobin glycation in diabetic condition |
| topic | Key words: Diabetes Glycation Hemoglobin Aspirin |
| url | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-117&slc_lang=en&sid=1 |
| work_keys_str_mv | AT adivsalar preservativeeffectsofaspirinonhumanhemoglobinglycationindiabeticcondition AT jbehroozi preservativeeffectsofaspirinonhumanhemoglobinglycationindiabeticcondition AT aasaboury preservativeeffectsofaspirinonhumanhemoglobinglycationindiabeticcondition AT nnpoursasan preservativeeffectsofaspirinonhumanhemoglobinglycationindiabeticcondition |