Pathological Spectrum and β-APP Immunoreactivity as a Diagnostic Tool of Diffuse Axonal Injury following Traumatic Brain Injury: A Novel Classification
Aim Different deposition patterns and grading systems used to define and identify DAI remain discordant and to date these are a challenge in clinical practice. Our main objective was to study the post-mortem axonal changes and develop a grading system to identify DAI on the basis of histo...
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| Format: | Article |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2023-09-01
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| Series: | Journal of Laboratory Physicians |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1761926 |
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| author | Meenakshi Sharma Arulselvi Subramaniam Kangana Sengar Vaishali Suri Deepak Agrawal Nabarun Chakraborty Ravindra Mohan Pandey Rajesh Malhotra Sanjeev Lalwani |
| author_facet | Meenakshi Sharma Arulselvi Subramaniam Kangana Sengar Vaishali Suri Deepak Agrawal Nabarun Chakraborty Ravindra Mohan Pandey Rajesh Malhotra Sanjeev Lalwani |
| author_sort | Meenakshi Sharma |
| collection | DOAJ |
| description |
Aim Different deposition patterns and grading systems used to define and identify DAI remain discordant and to date these are a challenge in clinical practice. Our main objective was to study the post-mortem axonal changes and develop a grading system to identify DAI on the basis of histopathological and immunoreactive β-amyloid precursor protein (β-APP) observations in severe TBI cases. |
| first_indexed | 2024-03-12T17:43:02Z |
| format | Article |
| id | doaj.art-cbf2bcef7b8f41bc99b90a3a5a16783c |
| institution | Directory Open Access Journal |
| issn | 0974-2727 0974-7826 |
| language | English |
| last_indexed | 2024-03-12T17:43:02Z |
| publishDate | 2023-09-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Journal of Laboratory Physicians |
| spelling | doaj.art-cbf2bcef7b8f41bc99b90a3a5a16783c2023-08-03T23:21:11ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Laboratory Physicians0974-27270974-78262023-09-01150339940810.1055/s-0043-1761926Pathological Spectrum and β-APP Immunoreactivity as a Diagnostic Tool of Diffuse Axonal Injury following Traumatic Brain Injury: A Novel ClassificationMeenakshi Sharma0Arulselvi Subramaniam1https://orcid.org/0000-0001-7797-6683Kangana Sengar2Vaishali Suri3Deepak Agrawal4Nabarun Chakraborty5Ravindra Mohan Pandey6Rajesh Malhotra7Sanjeev Lalwani8Division of Forensic Pathology and Molecular DNA Laboratory, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, IndiaNeuropathology Laboratory, Center for Neurosciences, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Neurosurgery, All India Institute of Medical Sciences, New Delhi, IndiaDivision of Forensic Pathology and Molecular DNA Laboratory, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Biostatistics, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Orthopaedics, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, IndiaDivision of Forensic Pathology and Molecular DNA Laboratory, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India Aim Different deposition patterns and grading systems used to define and identify DAI remain discordant and to date these are a challenge in clinical practice. Our main objective was to study the post-mortem axonal changes and develop a grading system to identify DAI on the basis of histopathological and immunoreactive β-amyloid precursor protein (β-APP) observations in severe TBI cases.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1761926traumatic brain injurydiffuse axonal injuryβ-appH&E stainforensic pathology |
| spellingShingle | Meenakshi Sharma Arulselvi Subramaniam Kangana Sengar Vaishali Suri Deepak Agrawal Nabarun Chakraborty Ravindra Mohan Pandey Rajesh Malhotra Sanjeev Lalwani Pathological Spectrum and β-APP Immunoreactivity as a Diagnostic Tool of Diffuse Axonal Injury following Traumatic Brain Injury: A Novel Classification Journal of Laboratory Physicians traumatic brain injury diffuse axonal injury β-app H&E stain forensic pathology |
| title | Pathological Spectrum and β-APP Immunoreactivity as a Diagnostic Tool of Diffuse Axonal Injury following Traumatic Brain Injury: A Novel Classification |
| title_full | Pathological Spectrum and β-APP Immunoreactivity as a Diagnostic Tool of Diffuse Axonal Injury following Traumatic Brain Injury: A Novel Classification |
| title_fullStr | Pathological Spectrum and β-APP Immunoreactivity as a Diagnostic Tool of Diffuse Axonal Injury following Traumatic Brain Injury: A Novel Classification |
| title_full_unstemmed | Pathological Spectrum and β-APP Immunoreactivity as a Diagnostic Tool of Diffuse Axonal Injury following Traumatic Brain Injury: A Novel Classification |
| title_short | Pathological Spectrum and β-APP Immunoreactivity as a Diagnostic Tool of Diffuse Axonal Injury following Traumatic Brain Injury: A Novel Classification |
| title_sort | pathological spectrum and β app immunoreactivity as a diagnostic tool of diffuse axonal injury following traumatic brain injury a novel classification |
| topic | traumatic brain injury diffuse axonal injury β-app H&E stain forensic pathology |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1761926 |
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