Suicide genes: monitoring cells in patients with a safety switch

Suicide genes: monitoring cells in patients with a safety switch

Clinical trials increasingly incorporate suicide genes either as direct lytic agents for tumors or as safety switches in therapies based on genetically modified cells. Suicide genes can also be used as non-invasive reporters to monitor the biological consequences of administering genetically modifie...

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Bibliographic Details
Main Authors:	Linda Groppe Eissenberg, Michael eRettig, Farrokh eDehdashti, David ePiwnica-Worms, John F. DiPersio
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2014-11-01
Series:	Frontiers in Pharmacology
Subjects:	Gene Therapy Regenerative Medicine Thymidine Kinase Suicide gene PET-imaging transplant biology
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00241/full

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