Cognitive Impact of Cerebellar Non-invasive Stimulation in a Patient With Schizophrenia
Cerebellum plays a role in the regulation of cognitive processes. Cerebellar alterations could explain cognitive impairments in schizophrenia. We describe the case of a 50 years old patient with schizophrenia whom underwent cerebellar transcranial direct current stimulation (tDCS). In order to study...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-03-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00174/full |
| _version_ | 1818310785936392192 |
|---|---|
| author | Charles Laidi Charles Laidi Charles Laidi Charles Laidi Carole Levenes Alex Suarez-Perez Caroline Février Florence Durand Noomane Bouaziz Dominique Januel |
| author_facet | Charles Laidi Charles Laidi Charles Laidi Charles Laidi Carole Levenes Alex Suarez-Perez Caroline Février Florence Durand Noomane Bouaziz Dominique Januel |
| author_sort | Charles Laidi |
| collection | DOAJ |
| description | Cerebellum plays a role in the regulation of cognitive processes. Cerebellar alterations could explain cognitive impairments in schizophrenia. We describe the case of a 50 years old patient with schizophrenia whom underwent cerebellar transcranial direct current stimulation (tDCS). In order to study the effect of cerebellar stimulation on cognitive functions, the patient underwent a neuropsychological assessment and an eyeblink conditioning (EBC) protocol. Although the effect of brain stimulation cannot be only assessed in a single-case study, our results suggest that cerebellar stimulation may have an effect on a broad range of cognitive functions typically impaired in patients with schizophrenia, including verbal episodic, short term, and working memory. In addition to neuropsychological tests, we evaluated the cerebellar function by performing EBC before and after tDCS. Our data suggest that tDCS can improve EBC. Further clinical trials are required for better understanding of how cerebellar stimulation can modulate cognitive processes in patients with schizophrenia and healthy controls. |
| first_indexed | 2024-12-13T07:51:35Z |
| format | Article |
| id | doaj.art-cbf71956e627422e9afa5e3a09604393 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-13T07:51:35Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-cbf71956e627422e9afa5e3a096043932022-12-21T23:54:39ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-03-011110.3389/fpsyt.2020.00174493546Cognitive Impact of Cerebellar Non-invasive Stimulation in a Patient With SchizophreniaCharles Laidi0Charles Laidi1Charles Laidi2Charles Laidi3Carole Levenes4Alex Suarez-Perez5Caroline Février6Florence Durand7Noomane Bouaziz8Dominique Januel9Pôle de Psychiatrie, Assistance Publique–Hôpitaux de Paris (AP-HP), Faculté de Médecine de Créteil, DMU IMPACT, Hôpitaux Universitaires Mondor, Créteil, FranceInstitut National de la Santé et de la Recherche Médicale (INSERM), U955, Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle, Créteil, FranceUNIACT, Psychiatry Team, Neurospin Neuroimaging Platform, CEA Saclay, Gif-sur-Yvette, FranceFondation Fondamental, Créteil, FranceIntegrative Neuroscience and Cognition Center (INCC UMR8002), Centre National de la Recherche Scientifique (CNRS), Institute for Neuroscience and Cognition, University of Paris, Paris, FranceIntegrative Neuroscience and Cognition Center (INCC UMR8002), Centre National de la Recherche Scientifique (CNRS), Institute for Neuroscience and Cognition, University of Paris, Paris, FrancePôle de Psychiatrie, Assistance Publique–Hôpitaux de Paris (AP-HP), Faculté de Médecine de Créteil, DMU IMPACT, Hôpitaux Universitaires Mondor, Créteil, FranceHôpital de Ville Evrard, Unité de Recherche Clinique, Neuilly-sur-Marne, FranceHôpital de Ville Evrard, Unité de Recherche Clinique, Neuilly-sur-Marne, FranceHôpital de Ville Evrard, Unité de Recherche Clinique, Neuilly-sur-Marne, FranceCerebellum plays a role in the regulation of cognitive processes. Cerebellar alterations could explain cognitive impairments in schizophrenia. We describe the case of a 50 years old patient with schizophrenia whom underwent cerebellar transcranial direct current stimulation (tDCS). In order to study the effect of cerebellar stimulation on cognitive functions, the patient underwent a neuropsychological assessment and an eyeblink conditioning (EBC) protocol. Although the effect of brain stimulation cannot be only assessed in a single-case study, our results suggest that cerebellar stimulation may have an effect on a broad range of cognitive functions typically impaired in patients with schizophrenia, including verbal episodic, short term, and working memory. In addition to neuropsychological tests, we evaluated the cerebellar function by performing EBC before and after tDCS. Our data suggest that tDCS can improve EBC. Further clinical trials are required for better understanding of how cerebellar stimulation can modulate cognitive processes in patients with schizophrenia and healthy controls.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00174/fullschizophreniatDCS—transcranial direct current stimulationcerebellumeyeblink conditioningcognition |
| spellingShingle | Charles Laidi Charles Laidi Charles Laidi Charles Laidi Carole Levenes Alex Suarez-Perez Caroline Février Florence Durand Noomane Bouaziz Dominique Januel Cognitive Impact of Cerebellar Non-invasive Stimulation in a Patient With Schizophrenia Frontiers in Psychiatry schizophrenia tDCS—transcranial direct current stimulation cerebellum eyeblink conditioning cognition |
| title | Cognitive Impact of Cerebellar Non-invasive Stimulation in a Patient With Schizophrenia |
| title_full | Cognitive Impact of Cerebellar Non-invasive Stimulation in a Patient With Schizophrenia |
| title_fullStr | Cognitive Impact of Cerebellar Non-invasive Stimulation in a Patient With Schizophrenia |
| title_full_unstemmed | Cognitive Impact of Cerebellar Non-invasive Stimulation in a Patient With Schizophrenia |
| title_short | Cognitive Impact of Cerebellar Non-invasive Stimulation in a Patient With Schizophrenia |
| title_sort | cognitive impact of cerebellar non invasive stimulation in a patient with schizophrenia |
| topic | schizophrenia tDCS—transcranial direct current stimulation cerebellum eyeblink conditioning cognition |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00174/full |
| work_keys_str_mv | AT charleslaidi cognitiveimpactofcerebellarnoninvasivestimulationinapatientwithschizophrenia AT charleslaidi cognitiveimpactofcerebellarnoninvasivestimulationinapatientwithschizophrenia AT charleslaidi cognitiveimpactofcerebellarnoninvasivestimulationinapatientwithschizophrenia AT charleslaidi cognitiveimpactofcerebellarnoninvasivestimulationinapatientwithschizophrenia AT carolelevenes cognitiveimpactofcerebellarnoninvasivestimulationinapatientwithschizophrenia AT alexsuarezperez cognitiveimpactofcerebellarnoninvasivestimulationinapatientwithschizophrenia AT carolinefevrier cognitiveimpactofcerebellarnoninvasivestimulationinapatientwithschizophrenia AT florencedurand cognitiveimpactofcerebellarnoninvasivestimulationinapatientwithschizophrenia AT noomanebouaziz cognitiveimpactofcerebellarnoninvasivestimulationinapatientwithschizophrenia AT dominiquejanuel cognitiveimpactofcerebellarnoninvasivestimulationinapatientwithschizophrenia |