Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol
Pterostilbene is a natural 3,5-dimethoxy analog of resveratrol. This stilbene compound has a strong bioactivity and exists widely in <i>Dalbergia</i> and <i>Vaccinium</i> spp. Besides natural extraction, pterostilbene can be obtained by biosynthesis. Pterostilbene has become...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/21/5166 |
| _version_ | 1797548705553842176 |
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| author | Yeju Liu Yuyang You Juan Lu Xi Chen Zhihong Yang |
| author_facet | Yeju Liu Yuyang You Juan Lu Xi Chen Zhihong Yang |
| author_sort | Yeju Liu |
| collection | DOAJ |
| description | Pterostilbene is a natural 3,5-dimethoxy analog of resveratrol. This stilbene compound has a strong bioactivity and exists widely in <i>Dalbergia</i> and <i>Vaccinium</i> spp. Besides natural extraction, pterostilbene can be obtained by biosynthesis. Pterostilbene has become popular because of its remarkable pharmacological activities, such as anti-tumor, anti-oxidation, anti-inflammation, and neuroprotection. Pterostilbene can be rapidly absorbed and is widely distributed in tissues, but it does not seriously accumulate in the body. Pterostilbene can easily pass through the blood-brain barrier because of its low molecular weight and good liposolubility. In this review, the studies performed in the last three years on resources, synthesis, bioactivity, and pharmacokinetics of pterostilbene are summarized. This review focuses on the effects of pterostilbene on certain diseases to explore its targets, explain the possible mechanism, and look for potential therapeutic applications. |
| first_indexed | 2024-03-10T15:03:26Z |
| format | Article |
| id | doaj.art-cbfa2010e25a436b952daf8a1c9a0f4d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:03:26Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-cbfa2010e25a436b952daf8a1c9a0f4d2023-11-20T19:58:53ZengMDPI AGMolecules1420-30492020-11-012521516610.3390/molecules25215166Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of ResveratrolYeju Liu0Yuyang You1Juan Lu2Xi Chen3Zhihong Yang4Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, ChinaSchool of Automation, Beijing Institute of Technology, Beijing 100081, ChinaInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, ChinaInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, ChinaInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, ChinaPterostilbene is a natural 3,5-dimethoxy analog of resveratrol. This stilbene compound has a strong bioactivity and exists widely in <i>Dalbergia</i> and <i>Vaccinium</i> spp. Besides natural extraction, pterostilbene can be obtained by biosynthesis. Pterostilbene has become popular because of its remarkable pharmacological activities, such as anti-tumor, anti-oxidation, anti-inflammation, and neuroprotection. Pterostilbene can be rapidly absorbed and is widely distributed in tissues, but it does not seriously accumulate in the body. Pterostilbene can easily pass through the blood-brain barrier because of its low molecular weight and good liposolubility. In this review, the studies performed in the last three years on resources, synthesis, bioactivity, and pharmacokinetics of pterostilbene are summarized. This review focuses on the effects of pterostilbene on certain diseases to explore its targets, explain the possible mechanism, and look for potential therapeutic applications.https://www.mdpi.com/1420-3049/25/21/5166pterostilbenesynthesisbioactivitypharmacokineticsresearch progress |
| spellingShingle | Yeju Liu Yuyang You Juan Lu Xi Chen Zhihong Yang Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol Molecules pterostilbene synthesis bioactivity pharmacokinetics research progress |
| title | Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol |
| title_full | Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol |
| title_fullStr | Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol |
| title_full_unstemmed | Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol |
| title_short | Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol |
| title_sort | recent advances in synthesis bioactivity and pharmacokinetics of pterostilbene an important analog of resveratrol |
| topic | pterostilbene synthesis bioactivity pharmacokinetics research progress |
| url | https://www.mdpi.com/1420-3049/25/21/5166 |
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