Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats
Alcohol misuse and, particularly adolescent drinking, is a major public health concern. While evidence suggests that adolescent alcohol use affects frontal brain regions that are important for cognitive control over behavior, little is known about how acute alcohol exposure alters large-scale brain...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Addiction Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772392523000482 |
| _version_ | 1797801664448561152 |
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| author | Sung-Ho Lee Tatiana A. Shnitko Li-Ming Hsu Margaret A. Broadwater Mabelle Sardinas Tzu-Wen Winnie Wang Donita L. Robinson Ryan P. Vetreno Fulton T. Crews Yen-Yu Ian Shih |
| author_facet | Sung-Ho Lee Tatiana A. Shnitko Li-Ming Hsu Margaret A. Broadwater Mabelle Sardinas Tzu-Wen Winnie Wang Donita L. Robinson Ryan P. Vetreno Fulton T. Crews Yen-Yu Ian Shih |
| author_sort | Sung-Ho Lee |
| collection | DOAJ |
| description | Alcohol misuse and, particularly adolescent drinking, is a major public health concern. While evidence suggests that adolescent alcohol use affects frontal brain regions that are important for cognitive control over behavior, little is known about how acute alcohol exposure alters large-scale brain networks and how sex and age may moderate such effects. Here, we employ a recently developed functional magnetic resonance imaging (fMRI) protocol to acquire rat brain functional connectivity data and use an established analytical pipeline to examine the effect of sex, age, and alcohol dose on connectivity within and between three major rodent brain networks: default mode, salience, and lateral cortical network. We identify the intra- and inter-network connectivity differences and establish moderation models to reveal significant influences of age on acute alcohol-induced lateral cortical network connectivity. Through this work, we make brain-wide isotropic fMRI data with acute alcohol challenge publicly available, with the hope to facilitate future discovery of brain regions/circuits that are causally relevant to the impact of acute alcohol use. |
| first_indexed | 2024-03-13T04:53:55Z |
| format | Article |
| id | doaj.art-cbfbbe1f250041839ea2cf20a97650c7 |
| institution | Directory Open Access Journal |
| issn | 2772-3925 |
| language | English |
| last_indexed | 2024-03-13T04:53:55Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Addiction Neuroscience |
| spelling | doaj.art-cbfbbe1f250041839ea2cf20a97650c72023-06-18T05:04:06ZengElsevierAddiction Neuroscience2772-39252023-09-017100105Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent ratsSung-Ho Lee0Tatiana A. Shnitko1Li-Ming Hsu2Margaret A. Broadwater3Mabelle Sardinas4Tzu-Wen Winnie Wang5Donita L. Robinson6Ryan P. Vetreno7Fulton T. Crews8Yen-Yu Ian Shih9Center for Animal MRI, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC, USA; Bowles Center for Alcohol Studies University of North Carolina, Chapel Hill, NC, USACenter for Animal MRI, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC, USACenter for Animal MRI, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC, USACenter for Animal MRI, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC, USA; Bowles Center for Alcohol Studies University of North Carolina, Chapel Hill, NC, USACenter for Animal MRI, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC, USACenter for Animal MRI, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC, USABowles Center for Alcohol Studies University of North Carolina, Chapel Hill, NC, USA; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USABowles Center for Alcohol Studies University of North Carolina, Chapel Hill, NC, USA; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USABowles Center for Alcohol Studies University of North Carolina, Chapel Hill, NC, USA; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USACenter for Animal MRI, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC, USA; Bowles Center for Alcohol Studies University of North Carolina, Chapel Hill, NC, USA; Corresponding author at: Center for Animal MRI, University of North Carolina, 125 Mason Farm Road, CB# 7513, Chapel Hill, NC 27599, USAAlcohol misuse and, particularly adolescent drinking, is a major public health concern. While evidence suggests that adolescent alcohol use affects frontal brain regions that are important for cognitive control over behavior, little is known about how acute alcohol exposure alters large-scale brain networks and how sex and age may moderate such effects. Here, we employ a recently developed functional magnetic resonance imaging (fMRI) protocol to acquire rat brain functional connectivity data and use an established analytical pipeline to examine the effect of sex, age, and alcohol dose on connectivity within and between three major rodent brain networks: default mode, salience, and lateral cortical network. We identify the intra- and inter-network connectivity differences and establish moderation models to reveal significant influences of age on acute alcohol-induced lateral cortical network connectivity. Through this work, we make brain-wide isotropic fMRI data with acute alcohol challenge publicly available, with the hope to facilitate future discovery of brain regions/circuits that are causally relevant to the impact of acute alcohol use.http://www.sciencedirect.com/science/article/pii/S2772392523000482Resting state fMRIConnectivityRatUnderage drinkingSexAge |
| spellingShingle | Sung-Ho Lee Tatiana A. Shnitko Li-Ming Hsu Margaret A. Broadwater Mabelle Sardinas Tzu-Wen Winnie Wang Donita L. Robinson Ryan P. Vetreno Fulton T. Crews Yen-Yu Ian Shih Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats Addiction Neuroscience Resting state fMRI Connectivity Rat Underage drinking Sex Age |
| title | Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats |
| title_full | Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats |
| title_fullStr | Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats |
| title_full_unstemmed | Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats |
| title_short | Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats |
| title_sort | acute alcohol induces greater dose dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats |
| topic | Resting state fMRI Connectivity Rat Underage drinking Sex Age |
| url | http://www.sciencedirect.com/science/article/pii/S2772392523000482 |
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