Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease
Chagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical course, ranging from symptomless infection to severe chronic disease with cardiovascular or gastrointestinal involvement or, occasionally, overwhelming acute episodes. The factors influencing this clinical variability...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
2004-02-01
|
| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000100001 |
| _version_ | 1797702931820052480 |
|---|---|
| author | Andréa M Macedo Carlos R Machado Riva P Oliveira Sérgio DJ Pena |
| author_facet | Andréa M Macedo Carlos R Machado Riva P Oliveira Sérgio DJ Pena |
| author_sort | Andréa M Macedo |
| collection | DOAJ |
| description | Chagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical course, ranging from symptomless infection to severe chronic disease with cardiovascular or gastrointestinal involvement or, occasionally, overwhelming acute episodes. The factors influencing this clinical variability have not been elucidated, but it is likely that the genetic variability of both the host and the parasite are of importance. In this work we review the the genetic structure of T. cruzi populations and analyze the importance of genetic variation of the parasite in the pathogenesis of the disease under the light of the histotropic-clonal model. |
| first_indexed | 2024-03-12T04:58:04Z |
| format | Article |
| id | doaj.art-cbfe484e58c54a89af8a6876e1d05468 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T04:58:04Z |
| publishDate | 2004-02-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-cbfe484e58c54a89af8a6876e1d054682023-09-03T09:14:42ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602004-02-0199111210.1590/S0074-02762004000100001Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas diseaseAndréa M MacedoCarlos R MachadoRiva P OliveiraSérgio DJ PenaChagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical course, ranging from symptomless infection to severe chronic disease with cardiovascular or gastrointestinal involvement or, occasionally, overwhelming acute episodes. The factors influencing this clinical variability have not been elucidated, but it is likely that the genetic variability of both the host and the parasite are of importance. In this work we review the the genetic structure of T. cruzi populations and analyze the importance of genetic variation of the parasite in the pathogenesis of the disease under the light of the histotropic-clonal model.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000100001Trypanosoma cruzigenetic variabilitymismatch repairpopulation structurepathogenesisChagas disease |
| spellingShingle | Andréa M Macedo Carlos R Machado Riva P Oliveira Sérgio DJ Pena Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease Memorias do Instituto Oswaldo Cruz Trypanosoma cruzi genetic variability mismatch repair population structure pathogenesis Chagas disease |
| title | Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease |
| title_full | Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease |
| title_fullStr | Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease |
| title_full_unstemmed | Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease |
| title_short | Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease |
| title_sort | trypanosoma cruzi genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease |
| topic | Trypanosoma cruzi genetic variability mismatch repair population structure pathogenesis Chagas disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000100001 |
| work_keys_str_mv | AT andreammacedo trypanosomacruzigeneticstructureofpopulationsandrelevanceofgeneticvariabilitytothepathogenesisofchagasdisease AT carlosrmachado trypanosomacruzigeneticstructureofpopulationsandrelevanceofgeneticvariabilitytothepathogenesisofchagasdisease AT rivapoliveira trypanosomacruzigeneticstructureofpopulationsandrelevanceofgeneticvariabilitytothepathogenesisofchagasdisease AT sergiodjpena trypanosomacruzigeneticstructureofpopulationsandrelevanceofgeneticvariabilitytothepathogenesisofchagasdisease |