Extracorporeal Hyperoxygenation Therapy (EHT) for Carbon Monoxide Poisoning: In-Vitro Proof of Principle
Carbon monoxide (CO) poisoning is the leading cause of poisoning-related deaths globally. The currently available therapy options are normobaric oxygen (NBO) and hyperbaric oxygen (HBO). While NBO lacks in efficacy, HBO is not available in all areas and countries. We present a novel method, extracor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Membranes |
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| Online Access: | https://www.mdpi.com/2077-0375/12/1/56 |
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| author | Niklas B. Steuer Peter C. Schlanstein Anke Hannig Stephan Sibirtsev Andreas Jupke Thomas Schmitz-Rode Rüdger Kopp Ulrich Steinseifer Georg Wagner Jutta Arens |
| author_facet | Niklas B. Steuer Peter C. Schlanstein Anke Hannig Stephan Sibirtsev Andreas Jupke Thomas Schmitz-Rode Rüdger Kopp Ulrich Steinseifer Georg Wagner Jutta Arens |
| author_sort | Niklas B. Steuer |
| collection | DOAJ |
| description | Carbon monoxide (CO) poisoning is the leading cause of poisoning-related deaths globally. The currently available therapy options are normobaric oxygen (NBO) and hyperbaric oxygen (HBO). While NBO lacks in efficacy, HBO is not available in all areas and countries. We present a novel method, extracorporeal hyperoxygenation therapy (EHT), for the treatment of CO poisoning that eliminates the CO by treating blood extracorporeally at elevated oxygen partial pressure. In this study, we proof the principle of the method in vitro using procine blood: Firstly, we investigated the difference in the CO elimination of a hollow fibre membrane oxygenator and a specifically designed batch oxygenator based on the bubble oxygenator principle at elevated pressures (1, 3 bar). Secondly, the batch oxygenator was redesigned and tested for a broader range of pressures (1, 3, 5, 7 bar) and temperatures (23, 30, 37 °C). So far, the shortest measured carboxyhemoglobin half-life in the blood was 21.32 min. In conclusion, EHT has the potential to provide an easily available and effective method for the treatment of CO poisoning. |
| first_indexed | 2024-03-10T00:59:02Z |
| format | Article |
| id | doaj.art-cbff5f4d0c7c4850af6529741bbec6f8 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-10T00:59:02Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-cbff5f4d0c7c4850af6529741bbec6f82023-11-23T14:38:37ZengMDPI AGMembranes2077-03752021-12-011215610.3390/membranes12010056Extracorporeal Hyperoxygenation Therapy (EHT) for Carbon Monoxide Poisoning: In-Vitro Proof of PrincipleNiklas B. Steuer0Peter C. Schlanstein1Anke Hannig2Stephan Sibirtsev3Andreas Jupke4Thomas Schmitz-Rode5Rüdger Kopp6Ulrich Steinseifer7Georg Wagner8Jutta Arens9Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, GermanyDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, GermanyDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, GermanyFluid Process Engineering (AVT.FVT), RWTH Aachen University, Forckenbeckstraße 51, 52074 Aachen, GermanyFluid Process Engineering (AVT.FVT), RWTH Aachen University, Forckenbeckstraße 51, 52074 Aachen, GermanyInstitute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, GermanyDepartment of Intensive Care Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, GermanyDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, GermanyDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, GermanyDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, GermanyCarbon monoxide (CO) poisoning is the leading cause of poisoning-related deaths globally. The currently available therapy options are normobaric oxygen (NBO) and hyperbaric oxygen (HBO). While NBO lacks in efficacy, HBO is not available in all areas and countries. We present a novel method, extracorporeal hyperoxygenation therapy (EHT), for the treatment of CO poisoning that eliminates the CO by treating blood extracorporeally at elevated oxygen partial pressure. In this study, we proof the principle of the method in vitro using procine blood: Firstly, we investigated the difference in the CO elimination of a hollow fibre membrane oxygenator and a specifically designed batch oxygenator based on the bubble oxygenator principle at elevated pressures (1, 3 bar). Secondly, the batch oxygenator was redesigned and tested for a broader range of pressures (1, 3, 5, 7 bar) and temperatures (23, 30, 37 °C). So far, the shortest measured carboxyhemoglobin half-life in the blood was 21.32 min. In conclusion, EHT has the potential to provide an easily available and effective method for the treatment of CO poisoning.https://www.mdpi.com/2077-0375/12/1/56carbon monoxidepoisoningextracorporeal therapyhyperoxygenationoxygenatorhollow fibre membrane oxygenator |
| spellingShingle | Niklas B. Steuer Peter C. Schlanstein Anke Hannig Stephan Sibirtsev Andreas Jupke Thomas Schmitz-Rode Rüdger Kopp Ulrich Steinseifer Georg Wagner Jutta Arens Extracorporeal Hyperoxygenation Therapy (EHT) for Carbon Monoxide Poisoning: In-Vitro Proof of Principle Membranes carbon monoxide poisoning extracorporeal therapy hyperoxygenation oxygenator hollow fibre membrane oxygenator |
| title | Extracorporeal Hyperoxygenation Therapy (EHT) for Carbon Monoxide Poisoning: In-Vitro Proof of Principle |
| title_full | Extracorporeal Hyperoxygenation Therapy (EHT) for Carbon Monoxide Poisoning: In-Vitro Proof of Principle |
| title_fullStr | Extracorporeal Hyperoxygenation Therapy (EHT) for Carbon Monoxide Poisoning: In-Vitro Proof of Principle |
| title_full_unstemmed | Extracorporeal Hyperoxygenation Therapy (EHT) for Carbon Monoxide Poisoning: In-Vitro Proof of Principle |
| title_short | Extracorporeal Hyperoxygenation Therapy (EHT) for Carbon Monoxide Poisoning: In-Vitro Proof of Principle |
| title_sort | extracorporeal hyperoxygenation therapy eht for carbon monoxide poisoning in vitro proof of principle |
| topic | carbon monoxide poisoning extracorporeal therapy hyperoxygenation oxygenator hollow fibre membrane oxygenator |
| url | https://www.mdpi.com/2077-0375/12/1/56 |
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