Expression of DNA-damage response and repair genes after exposure to DNA-damaging agents in isogenic head and neck cells with altered radiosensitivity
Increased radioresistance due to previous irradiation or radiosensitivity due to human papilloma virus (HPV) infection can be observed in head and neck squamous cell carcinoma (HNSCC). The DNA-damage response of cells after exposure to DNA-damaging agents plays a crucial role in determining the fate...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2022-04-01
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| Series: | Radiology and Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/raon-2022-0014 |
| _version_ | 1797848532110016512 |
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| author | Todorovic Vesna Groselj Blaz Cemazar Maja Prevc Ajda Zakelj Martina Niksic Strojan Primoz Sersa Gregor |
| author_facet | Todorovic Vesna Groselj Blaz Cemazar Maja Prevc Ajda Zakelj Martina Niksic Strojan Primoz Sersa Gregor |
| author_sort | Todorovic Vesna |
| collection | DOAJ |
| description | Increased radioresistance due to previous irradiation or radiosensitivity due to human papilloma virus (HPV) infection can be observed in head and neck squamous cell carcinoma (HNSCC). The DNA-damage response of cells after exposure to DNA-damaging agents plays a crucial role in determining the fate of exposed cells. Tightly regulated and interconnected signaling networks are activated to detect, signal the presence of and repair the DNA damage. Novel therapies targeting the DNA-damage response are emerging; however, an improved understanding of the complex signaling networks involved in tumor radioresistance and radiosensitivity is needed. |
| first_indexed | 2024-04-09T18:30:12Z |
| format | Article |
| id | doaj.art-cc01565e70bb4fc192a41b9b2df028b8 |
| institution | Directory Open Access Journal |
| issn | 1581-3207 |
| language | English |
| last_indexed | 2024-04-09T18:30:12Z |
| publishDate | 2022-04-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Radiology and Oncology |
| spelling | doaj.art-cc01565e70bb4fc192a41b9b2df028b82023-04-11T17:19:28ZengSciendoRadiology and Oncology1581-32072022-04-0156217318410.2478/raon-2022-0014Expression of DNA-damage response and repair genes after exposure to DNA-damaging agents in isogenic head and neck cells with altered radiosensitivityTodorovic Vesna0Groselj Blaz1Cemazar Maja2Prevc Ajda3Zakelj Martina Niksic4Strojan Primoz5Sersa Gregor6Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, SloveniaDepartment of Radiation Oncology, Institute of Oncology Ljubljana, Ljubljana, SloveniaDepartment of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, SloveniaDepartment of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, SloveniaDepartment of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, SloveniaDepartment of Radiation Oncology, Institute of Oncology Ljubljana, Ljubljana, SloveniaDepartment of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, SloveniaIncreased radioresistance due to previous irradiation or radiosensitivity due to human papilloma virus (HPV) infection can be observed in head and neck squamous cell carcinoma (HNSCC). The DNA-damage response of cells after exposure to DNA-damaging agents plays a crucial role in determining the fate of exposed cells. Tightly regulated and interconnected signaling networks are activated to detect, signal the presence of and repair the DNA damage. Novel therapies targeting the DNA-damage response are emerging; however, an improved understanding of the complex signaling networks involved in tumor radioresistance and radiosensitivity is needed.https://doi.org/10.2478/raon-2022-0014head and neck cancersquamous cell carcinomaradioresistanceirradiationdna-damaging agentsgene expression profiles |
| spellingShingle | Todorovic Vesna Groselj Blaz Cemazar Maja Prevc Ajda Zakelj Martina Niksic Strojan Primoz Sersa Gregor Expression of DNA-damage response and repair genes after exposure to DNA-damaging agents in isogenic head and neck cells with altered radiosensitivity Radiology and Oncology head and neck cancer squamous cell carcinoma radioresistance irradiation dna-damaging agents gene expression profiles |
| title | Expression of DNA-damage response and repair genes after exposure to DNA-damaging agents in isogenic head and neck cells with altered radiosensitivity |
| title_full | Expression of DNA-damage response and repair genes after exposure to DNA-damaging agents in isogenic head and neck cells with altered radiosensitivity |
| title_fullStr | Expression of DNA-damage response and repair genes after exposure to DNA-damaging agents in isogenic head and neck cells with altered radiosensitivity |
| title_full_unstemmed | Expression of DNA-damage response and repair genes after exposure to DNA-damaging agents in isogenic head and neck cells with altered radiosensitivity |
| title_short | Expression of DNA-damage response and repair genes after exposure to DNA-damaging agents in isogenic head and neck cells with altered radiosensitivity |
| title_sort | expression of dna damage response and repair genes after exposure to dna damaging agents in isogenic head and neck cells with altered radiosensitivity |
| topic | head and neck cancer squamous cell carcinoma radioresistance irradiation dna-damaging agents gene expression profiles |
| url | https://doi.org/10.2478/raon-2022-0014 |
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