Expression of DNA-damage response and repair genes after exposure to DNA-damaging agents in isogenic head and neck cells with altered radiosensitivity

Expression of DNA-damage response and repair genes after exposure to DNA-damaging agents in isogenic head and neck cells with altered radiosensitivity

Increased radioresistance due to previous irradiation or radiosensitivity due to human papilloma virus (HPV) infection can be observed in head and neck squamous cell carcinoma (HNSCC). The DNA-damage response of cells after exposure to DNA-damaging agents plays a crucial role in determining the fate...

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Bibliographic Details
Main Authors: Todorovic Vesna, Groselj Blaz, Cemazar Maja, Prevc Ajda, Zakelj Martina Niksic, Strojan Primoz, Sersa Gregor
Format: Article
Language:English
Published: Sciendo 2022-04-01
Series:Radiology and Oncology
Subjects:
head and neck cancer
squamous cell carcinoma
radioresistance
irradiation
dna-damaging agents
gene expression profiles
Online Access:https://doi.org/10.2478/raon-2022-0014

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