Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders
The past decades have yielded major therapeutic advances in many autoimmune conditions – such as multiple sclerosis (MS) – and thus ushered in a new era of more targeted and increasingly potent immunotherapies. Yet this growing arsenal of therapeutic immune interventions has also rendered therapy mu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-08-01
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| Series: | Therapeutic Advances in Neurological Disorders |
| Online Access: | https://doi.org/10.1177/17562864211035542 |
| _version_ | 1819017746486132736 |
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| author | Tobias Brummer Tobias Ruck Sven G. Meuth Frauke Zipp Stefan Bittner |
| author_facet | Tobias Brummer Tobias Ruck Sven G. Meuth Frauke Zipp Stefan Bittner |
| author_sort | Tobias Brummer |
| collection | DOAJ |
| description | The past decades have yielded major therapeutic advances in many autoimmune conditions – such as multiple sclerosis (MS) – and thus ushered in a new era of more targeted and increasingly potent immunotherapies. Yet this growing arsenal of therapeutic immune interventions has also rendered therapy much more challenging for the attending physician, especially when treating patients with more than one autoimmune condition. Importantly, some therapeutic strategies are either approved for several autoimmune disorders or may be repurposed for other conditions, therefore opening new curative possibilities in related fields. In this article, we especially focus on frequent and therapeutically relevant concomitant autoimmune conditions faced by neurologists when treating patients with MS, namely psoriasis, rheumatoid arthritis and inflammatory bowel diseases. We provide an overview of the available disease-modifying therapies, highlight possible contraindications, show pathophysiological overlaps and finally present which therapeutics can be utilized as a combinatory treatment, in order to ‘kill two birds with one stone’. |
| first_indexed | 2024-12-21T03:08:25Z |
| format | Article |
| id | doaj.art-cc0197de52544222925e1e9dcc249fe1 |
| institution | Directory Open Access Journal |
| issn | 1756-2864 |
| language | English |
| last_indexed | 2024-12-21T03:08:25Z |
| publishDate | 2021-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Neurological Disorders |
| spelling | doaj.art-cc0197de52544222925e1e9dcc249fe12022-12-21T19:18:03ZengSAGE PublishingTherapeutic Advances in Neurological Disorders1756-28642021-08-011410.1177/17562864211035542Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disordersTobias BrummerTobias RuckSven G. MeuthFrauke ZippStefan BittnerThe past decades have yielded major therapeutic advances in many autoimmune conditions – such as multiple sclerosis (MS) – and thus ushered in a new era of more targeted and increasingly potent immunotherapies. Yet this growing arsenal of therapeutic immune interventions has also rendered therapy much more challenging for the attending physician, especially when treating patients with more than one autoimmune condition. Importantly, some therapeutic strategies are either approved for several autoimmune disorders or may be repurposed for other conditions, therefore opening new curative possibilities in related fields. In this article, we especially focus on frequent and therapeutically relevant concomitant autoimmune conditions faced by neurologists when treating patients with MS, namely psoriasis, rheumatoid arthritis and inflammatory bowel diseases. We provide an overview of the available disease-modifying therapies, highlight possible contraindications, show pathophysiological overlaps and finally present which therapeutics can be utilized as a combinatory treatment, in order to ‘kill two birds with one stone’.https://doi.org/10.1177/17562864211035542 |
| spellingShingle | Tobias Brummer Tobias Ruck Sven G. Meuth Frauke Zipp Stefan Bittner Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders Therapeutic Advances in Neurological Disorders |
| title | Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders |
| title_full | Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders |
| title_fullStr | Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders |
| title_full_unstemmed | Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders |
| title_short | Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders |
| title_sort | treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders |
| url | https://doi.org/10.1177/17562864211035542 |
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