Endoplasmic reticulum stress promoted acinar cell necroptosis in acute pancreatitis through cathepsinB-mediated AP-1 activation

Endoplasmic reticulum stress promoted acinar cell necroptosis in acute pancreatitis through cathepsinB-mediated AP-1 activation

Acinar cell death and inflammatory response are two important events which determine the severity of acute pancreatitis (AP). Endoplasmic reticulum (ER) stress and necroptosis are involved in this process, but the relationships between them remain unknown. Here, we analyzed the interaction between E...

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Bibliographic Details
Main Authors: Xiao Han, Bin Li, Jingpiao Bao, Zengkai Wu, Congying Chen, Jianbo Ni, Jie Shen, Pengli Song, Qi Peng, Rong Wan, Xingpeng Wang, Jianghong Wu, Guoyong Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
acute pancreatitis
endoplasmic reticulum stress
necroptosis
cathepsin B
activating protein-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.968639/full

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