Peanut-natto improved obesity of high-fat diet mice by regulating gut microbiota and lipid metabolism
Globally, the incidence of diseases such as obesity, fatty liver and hyperlipidaemia has increased drastically in recent years. This study investigated the direct treatment of obesity and its associated metabolic disorders using peanut-natto in a high-fat diet (HFD)–induced mouse model of obesity. A...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646462300556X |
| _version_ | 1797356159158452224 |
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| author | Shufang Cao Lina Yang Mengxi Xie Miao Yu Taiyuan Shi |
| author_facet | Shufang Cao Lina Yang Mengxi Xie Miao Yu Taiyuan Shi |
| author_sort | Shufang Cao |
| collection | DOAJ |
| description | Globally, the incidence of diseases such as obesity, fatty liver and hyperlipidaemia has increased drastically in recent years. This study investigated the direct treatment of obesity and its associated metabolic disorders using peanut-natto in a high-fat diet (HFD)–induced mouse model of obesity. After 6 weeks of treatment, peanut-natto significantly reduced the body and abdominal fat weight of mice with obesity, decreased the fat cell area and fat droplet accumulation in the liver and improved the colon structure by regulating the levels of intestinal lipid metabolism-related proteins such as CD36 and FATP4. Compared with the untreated HFD group, peanut-natto significantly reduced the serum levels of LDL-C, TG and T-CHO. Metagenomic analysis revealed that natto can restore the abundance of gut microbiota to a certain extent and increase the Bacteroidetes-to-Firmicutes ratio. Non-targeted metabolomics analysis indicated a metabolism disorder that was obviously improved by peanut-natto treatment via the regulation of α-linolenic acid metabolism, linoleic acid metabolism, unsaturated fatty acid biosynthesis and lipid decomposition in fat cells. These results provide a scientific basis for using peanut-natto as a new food product to prevent obesity, improve metabolic disorders and balance the intestinal microbiota. |
| first_indexed | 2024-03-08T14:22:37Z |
| format | Article |
| id | doaj.art-cc046bd6420c4615910c122297c2cbda |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-08T14:22:37Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-cc046bd6420c4615910c122297c2cbda2024-01-14T05:37:20ZengElsevierJournal of Functional Foods1756-46462024-01-01112105956Peanut-natto improved obesity of high-fat diet mice by regulating gut microbiota and lipid metabolismShufang Cao0Lina Yang1Mengxi Xie2Miao Yu3Taiyuan Shi4College of Food Science and Engineering, Bohai University, Jinzhou, Liaoning 121013, ChinaCollege of Food Science and Engineering, Bohai University, Jinzhou, Liaoning 121013, China; Food and Processing Research Institute, Liaoning Academy of Agricultural Sciences, Shenyang, Liaoning 110161, China; Corresponding authors at: College of Food Science and Engineering, Bohai University, 19 Keji Road, Songshan New Region, Jinzhou, Liaoning 121013, China (L. Yang). Food and Processing Research Institute, Liaoning Academy of Agricultural Sciences, 84 Dongling Road, Shenhe Region, Shenyang, Liaoning 110161, China (T. Shi).Food and Processing Research Institute, Liaoning Academy of Agricultural Sciences, Shenyang, Liaoning 110161, ChinaFood and Processing Research Institute, Liaoning Academy of Agricultural Sciences, Shenyang, Liaoning 110161, ChinaFood and Processing Research Institute, Liaoning Academy of Agricultural Sciences, Shenyang, Liaoning 110161, China; Corresponding authors at: College of Food Science and Engineering, Bohai University, 19 Keji Road, Songshan New Region, Jinzhou, Liaoning 121013, China (L. Yang). Food and Processing Research Institute, Liaoning Academy of Agricultural Sciences, 84 Dongling Road, Shenhe Region, Shenyang, Liaoning 110161, China (T. Shi).Globally, the incidence of diseases such as obesity, fatty liver and hyperlipidaemia has increased drastically in recent years. This study investigated the direct treatment of obesity and its associated metabolic disorders using peanut-natto in a high-fat diet (HFD)–induced mouse model of obesity. After 6 weeks of treatment, peanut-natto significantly reduced the body and abdominal fat weight of mice with obesity, decreased the fat cell area and fat droplet accumulation in the liver and improved the colon structure by regulating the levels of intestinal lipid metabolism-related proteins such as CD36 and FATP4. Compared with the untreated HFD group, peanut-natto significantly reduced the serum levels of LDL-C, TG and T-CHO. Metagenomic analysis revealed that natto can restore the abundance of gut microbiota to a certain extent and increase the Bacteroidetes-to-Firmicutes ratio. Non-targeted metabolomics analysis indicated a metabolism disorder that was obviously improved by peanut-natto treatment via the regulation of α-linolenic acid metabolism, linoleic acid metabolism, unsaturated fatty acid biosynthesis and lipid decomposition in fat cells. These results provide a scientific basis for using peanut-natto as a new food product to prevent obesity, improve metabolic disorders and balance the intestinal microbiota.http://www.sciencedirect.com/science/article/pii/S175646462300556XPeanut-nattoObesity miceGut microbiotaLipid metabolism |
| spellingShingle | Shufang Cao Lina Yang Mengxi Xie Miao Yu Taiyuan Shi Peanut-natto improved obesity of high-fat diet mice by regulating gut microbiota and lipid metabolism Journal of Functional Foods Peanut-natto Obesity mice Gut microbiota Lipid metabolism |
| title | Peanut-natto improved obesity of high-fat diet mice by regulating gut microbiota and lipid metabolism |
| title_full | Peanut-natto improved obesity of high-fat diet mice by regulating gut microbiota and lipid metabolism |
| title_fullStr | Peanut-natto improved obesity of high-fat diet mice by regulating gut microbiota and lipid metabolism |
| title_full_unstemmed | Peanut-natto improved obesity of high-fat diet mice by regulating gut microbiota and lipid metabolism |
| title_short | Peanut-natto improved obesity of high-fat diet mice by regulating gut microbiota and lipid metabolism |
| title_sort | peanut natto improved obesity of high fat diet mice by regulating gut microbiota and lipid metabolism |
| topic | Peanut-natto Obesity mice Gut microbiota Lipid metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S175646462300556X |
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