Fibromyalgia: A Review of Related Polymorphisms and Clinical Relevance
Abstract Fibromyalgia (FM) is a chronic pain syndrome that affects the central nervous system and generates disability, which is characterized by generalized pain, fatigue, and functional decline. In this review, we aimed to identify the polymorphisms related to the pathophysiology of FM and the cli...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2021-11-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000800702&tlng=en |
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| author | LUÍSA P. JANSSEN LICIANE F. MEDEIROS ANDRESSA DE SOUZA JULIANA DA SILVA |
| author_facet | LUÍSA P. JANSSEN LICIANE F. MEDEIROS ANDRESSA DE SOUZA JULIANA DA SILVA |
| author_sort | LUÍSA P. JANSSEN |
| collection | DOAJ |
| description | Abstract Fibromyalgia (FM) is a chronic pain syndrome that affects the central nervous system and generates disability, which is characterized by generalized pain, fatigue, and functional decline. In this review, we aimed to identify the polymorphisms related to the pathophysiology of FM and the clinical characteristics generated by genetic influence. Only original studies with genes related to FM were considered, totaling 27 articles. The genes found were: MTHFR, RGS4, MYT1L, TACR1, SCN9A, DRD3, ADRB2, IL-4, HLA-DRB1, EDN1, CNR1, TAAR1, OPRM1, ADRA1A, ADRB3, BDNF, GRIA4, HTR3A, HTR3B, HTR2A, SERPINA 1 or A1AT, NRXN3, GCH1, MEFV, TRPV3, SLC6A4, ACE I/D, TSPO, COMT, and MAOA. Several genes related to different pain syndromes and altered pain thresholds have been identified and some polymorphisms were related to susceptibility to FM. It was observed that 73.33% of the genes related to FM were also associated with some psychological disorders, such as anxiety, depression, schizophrenia, and obsessive and compulsive disorder, and 40.00% with pain sensitivity and/or migraine, besides other disorders associated (drug addiction, autoimmune disorders, circulatory problems, and metabolic alterations). This review demonstrated an association of FM and genetic polymorphisms that can expand our knowledge about the pathophysiology of this disease. |
| first_indexed | 2024-12-18T02:55:49Z |
| format | Article |
| id | doaj.art-cc0475c6aff24cfbbadcbbf9760f3e9a |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-12-18T02:55:49Z |
| publishDate | 2021-11-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-cc0475c6aff24cfbbadcbbf9760f3e9a2022-12-21T21:23:22ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902021-11-0193suppl 410.1590/0001-3765202120210618Fibromyalgia: A Review of Related Polymorphisms and Clinical RelevanceLUÍSA P. JANSSENhttps://orcid.org/0000-0001-7934-9499LICIANE F. MEDEIROShttps://orcid.org/0000-0002-6842-7241ANDRESSA DE SOUZAhttps://orcid.org/0000-0002-6608-4695JULIANA DA SILVAhttps://orcid.org/0000-0002-1089-6766Abstract Fibromyalgia (FM) is a chronic pain syndrome that affects the central nervous system and generates disability, which is characterized by generalized pain, fatigue, and functional decline. In this review, we aimed to identify the polymorphisms related to the pathophysiology of FM and the clinical characteristics generated by genetic influence. Only original studies with genes related to FM were considered, totaling 27 articles. The genes found were: MTHFR, RGS4, MYT1L, TACR1, SCN9A, DRD3, ADRB2, IL-4, HLA-DRB1, EDN1, CNR1, TAAR1, OPRM1, ADRA1A, ADRB3, BDNF, GRIA4, HTR3A, HTR3B, HTR2A, SERPINA 1 or A1AT, NRXN3, GCH1, MEFV, TRPV3, SLC6A4, ACE I/D, TSPO, COMT, and MAOA. Several genes related to different pain syndromes and altered pain thresholds have been identified and some polymorphisms were related to susceptibility to FM. It was observed that 73.33% of the genes related to FM were also associated with some psychological disorders, such as anxiety, depression, schizophrenia, and obsessive and compulsive disorder, and 40.00% with pain sensitivity and/or migraine, besides other disorders associated (drug addiction, autoimmune disorders, circulatory problems, and metabolic alterations). This review demonstrated an association of FM and genetic polymorphisms that can expand our knowledge about the pathophysiology of this disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000800702&tlng=enfibromyalgiagenepolymorphismsSNPs |
| spellingShingle | LUÍSA P. JANSSEN LICIANE F. MEDEIROS ANDRESSA DE SOUZA JULIANA DA SILVA Fibromyalgia: A Review of Related Polymorphisms and Clinical Relevance Anais da Academia Brasileira de Ciências fibromyalgia gene polymorphisms SNPs |
| title | Fibromyalgia: A Review of Related Polymorphisms and Clinical Relevance |
| title_full | Fibromyalgia: A Review of Related Polymorphisms and Clinical Relevance |
| title_fullStr | Fibromyalgia: A Review of Related Polymorphisms and Clinical Relevance |
| title_full_unstemmed | Fibromyalgia: A Review of Related Polymorphisms and Clinical Relevance |
| title_short | Fibromyalgia: A Review of Related Polymorphisms and Clinical Relevance |
| title_sort | fibromyalgia a review of related polymorphisms and clinical relevance |
| topic | fibromyalgia gene polymorphisms SNPs |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000800702&tlng=en |
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