The Effects of Magnesium Sulfate Loading on Hemodynamic Parameters During Laparoscopic Cholecystectomy: Randomized Controlled Trial
Background: This study was designed to investigate the effect of intravenous magnesium sulfate on hemodynamic changes induced by pneumoperitoneum in patients undergoing laparoscopic cholecystectomy. Methods: A randomized, placebo controlled study was performed on 52 ASA class I or II aged 20-70 year...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2017-04-01
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| Series: | Archives of Anesthesia and Critical Care |
| Subjects: | |
| Online Access: | https://aacc.tums.ac.ir/index.php/aacc/article/view/108 |
| _version_ | 1811280174702919680 |
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| author | Mohammad Reza Ghodraty Mohammad Mahdi Zamani Shahin Jamili Alireza Pournajafian Parisa Salemi Behshid Ghadrdoost Seyyedeh Fatemeh Parsa Alireza Kholdebarin Mohammad Tashayoei Ali Mougouee |
| author_facet | Mohammad Reza Ghodraty Mohammad Mahdi Zamani Shahin Jamili Alireza Pournajafian Parisa Salemi Behshid Ghadrdoost Seyyedeh Fatemeh Parsa Alireza Kholdebarin Mohammad Tashayoei Ali Mougouee |
| author_sort | Mohammad Reza Ghodraty |
| collection | DOAJ |
| description | Background: This study was designed to investigate the effect of intravenous magnesium sulfate on hemodynamic changes induced by pneumoperitoneum in patients undergoing laparoscopic cholecystectomy.
Methods: A randomized, placebo controlled study was performed on 52 ASA class I or II aged 20-70 years patients undergoing laparoscopic cholecystectomy with pneumoperitoneum with carbon dioxide. Before induction, Magnesium group received 50 mcg.kg-1 magnesium sulfate, within 10 minutes, in 100 ml of normal saline and control group received 100 ml normal saline. Hemodynamic variables were recorded before induction, before the infusion of magnesium sulfate, during intubation, during pneumoperitoneum and finally during extubation, every 10 minutes. Postoperative pain and other complications were recorded in post anesthesia care unit (PACU) also.
Results: Variations in heart rate and mean arterial pressure between the two groups during pneumoperitoneum were not significantly different (P>0.05). Propofol consumption in the magnesium group compared with the control group was significantly decreased (P<0.05). The prescribed dose of TNG and total amount of administrated TNG (SUM), both were significantly higher in control group than in the magnesium group (respectively P=0.02 and P=0.042). In PACU, patients in the magnesium presented lower shivering, nausea vomiting and post operative pain than the control group (P <0.05).
Conclusion: Magnesium sulfate reduces the amount of anesthetic drug (propofol), TNG and intraoperative blood pressure, during pneumoperitoneum induced by laparoscopy. The postoperative pain of laparoscopy and anesthesia side effects such as nausea, vomiting and shivering were blunted, with bolus administration of magnesium sulfate before induction of anesthesia. |
| first_indexed | 2024-04-13T01:09:18Z |
| format | Article |
| id | doaj.art-cc04a4de75e24f949843209a97513c97 |
| institution | Directory Open Access Journal |
| issn | 2423-5849 |
| language | English |
| last_indexed | 2024-04-13T01:09:18Z |
| publishDate | 2017-04-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Archives of Anesthesia and Critical Care |
| spelling | doaj.art-cc04a4de75e24f949843209a97513c972022-12-22T03:09:14ZengTehran University of Medical SciencesArchives of Anesthesia and Critical Care2423-58492017-04-0132The Effects of Magnesium Sulfate Loading on Hemodynamic Parameters During Laparoscopic Cholecystectomy: Randomized Controlled TrialMohammad Reza Ghodraty0Mohammad Mahdi Zamani1Shahin Jamili2Alireza Pournajafian3Parisa Salemi4Behshid Ghadrdoost5Seyyedeh Fatemeh Parsa6Alireza Kholdebarin7Mohammad Tashayoei8Ali Mougouee9Department of Anesthesiology and Pain Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranDepartment of Anesthesiology and Pain Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran, AND Department of Anesthesiology and Critical Care, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Anesthesiology and Critical Care, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of General surgery, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranDepartment of Anesthesiology and Pain Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranDepartment of midwifery, Faculty of Nursing & Midwifery, Karaj Branch, Islamic Azad University, Alborz, IranDepartment of Anesthesiology and Pain Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranDepartment of Anesthesiology and Pain Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranDepartment of Anesthesiology and Pain Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranDepartment of General surgery, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranDepartment of Anesthesiology and Pain Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranBackground: This study was designed to investigate the effect of intravenous magnesium sulfate on hemodynamic changes induced by pneumoperitoneum in patients undergoing laparoscopic cholecystectomy. Methods: A randomized, placebo controlled study was performed on 52 ASA class I or II aged 20-70 years patients undergoing laparoscopic cholecystectomy with pneumoperitoneum with carbon dioxide. Before induction, Magnesium group received 50 mcg.kg-1 magnesium sulfate, within 10 minutes, in 100 ml of normal saline and control group received 100 ml normal saline. Hemodynamic variables were recorded before induction, before the infusion of magnesium sulfate, during intubation, during pneumoperitoneum and finally during extubation, every 10 minutes. Postoperative pain and other complications were recorded in post anesthesia care unit (PACU) also. Results: Variations in heart rate and mean arterial pressure between the two groups during pneumoperitoneum were not significantly different (P>0.05). Propofol consumption in the magnesium group compared with the control group was significantly decreased (P<0.05). The prescribed dose of TNG and total amount of administrated TNG (SUM), both were significantly higher in control group than in the magnesium group (respectively P=0.02 and P=0.042). In PACU, patients in the magnesium presented lower shivering, nausea vomiting and post operative pain than the control group (P <0.05). Conclusion: Magnesium sulfate reduces the amount of anesthetic drug (propofol), TNG and intraoperative blood pressure, during pneumoperitoneum induced by laparoscopy. The postoperative pain of laparoscopy and anesthesia side effects such as nausea, vomiting and shivering were blunted, with bolus administration of magnesium sulfate before induction of anesthesia.https://aacc.tums.ac.ir/index.php/aacc/article/view/108carbon dioxidehemodynamicslaparoscopymagnesium sulfate |
| spellingShingle | Mohammad Reza Ghodraty Mohammad Mahdi Zamani Shahin Jamili Alireza Pournajafian Parisa Salemi Behshid Ghadrdoost Seyyedeh Fatemeh Parsa Alireza Kholdebarin Mohammad Tashayoei Ali Mougouee The Effects of Magnesium Sulfate Loading on Hemodynamic Parameters During Laparoscopic Cholecystectomy: Randomized Controlled Trial Archives of Anesthesia and Critical Care carbon dioxide hemodynamics laparoscopy magnesium sulfate |
| title | The Effects of Magnesium Sulfate Loading on Hemodynamic Parameters During Laparoscopic Cholecystectomy: Randomized Controlled Trial |
| title_full | The Effects of Magnesium Sulfate Loading on Hemodynamic Parameters During Laparoscopic Cholecystectomy: Randomized Controlled Trial |
| title_fullStr | The Effects of Magnesium Sulfate Loading on Hemodynamic Parameters During Laparoscopic Cholecystectomy: Randomized Controlled Trial |
| title_full_unstemmed | The Effects of Magnesium Sulfate Loading on Hemodynamic Parameters During Laparoscopic Cholecystectomy: Randomized Controlled Trial |
| title_short | The Effects of Magnesium Sulfate Loading on Hemodynamic Parameters During Laparoscopic Cholecystectomy: Randomized Controlled Trial |
| title_sort | effects of magnesium sulfate loading on hemodynamic parameters during laparoscopic cholecystectomy randomized controlled trial |
| topic | carbon dioxide hemodynamics laparoscopy magnesium sulfate |
| url | https://aacc.tums.ac.ir/index.php/aacc/article/view/108 |
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