EXPERIMENTAL MODEL OF THE PRIMARY MALE HYPOGONADISM
Background: Development of the new methods of treatment of primary male hypogonadism is an urgent medical problem. Its solution requires a suitable experimental model of the disease. Aim: The creation of new experimental model of primary male hypogonadism. Materials and methods: The study was conduc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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MONIKI
2016-02-01
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| Series: | Alʹmanah Kliničeskoj Mediciny |
| Subjects: | |
| Online Access: | https://www.almclinmed.ru/jour/article/view/53 |
| _version_ | 1818694153774563328 |
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| author | P. A. Kulikova Yu. N. Filyushkin D. A. Kulikov A. V. Fedulov A. E. Mashkov A. V. Kulikov |
| author_facet | P. A. Kulikova Yu. N. Filyushkin D. A. Kulikov A. V. Fedulov A. E. Mashkov A. V. Kulikov |
| author_sort | P. A. Kulikova |
| collection | DOAJ |
| description | Background: Development of the new methods of treatment of primary male hypogonadism is an urgent medical problem. Its solution requires a suitable experimental model of the disease. Aim: The creation of new experimental model of primary male hypogonadism. Materials and methods: The study was conducted on the male Wistar rats, hypogonadism was modeled by temporary ligation of the distal part of the spermatic cord. Results: It was shown that three-day ligation of the spermatic cord led to persistent disturbance of the testosterone-producing and reproductive functions. These manifestations were reversible at shorter duration of the exposure. Conclusion: The created model of primary male hypogonadism is characterized by the persistent testosterone-producing and reproductive functions disturbance, technical availability, non-toxicity to the other organs and systems. Availability of the model provides new opportunities for the development of approaches to treating diseases of the reproductive organs in men. |
| first_indexed | 2024-12-17T13:25:03Z |
| format | Article |
| id | doaj.art-cc08ee0fc3304bd79c877a676360f977 |
| institution | Directory Open Access Journal |
| issn | 2072-0505 2587-9294 |
| language | Russian |
| last_indexed | 2024-12-17T13:25:03Z |
| publishDate | 2016-02-01 |
| publisher | MONIKI |
| record_format | Article |
| series | Alʹmanah Kliničeskoj Mediciny |
| spelling | doaj.art-cc08ee0fc3304bd79c877a676360f9772022-12-21T21:46:46ZrusMONIKIAlʹmanah Kliničeskoj Mediciny2072-05052587-92942016-02-01131212410.18786/2072-0505-2014-31-21-2453EXPERIMENTAL MODEL OF THE PRIMARY MALE HYPOGONADISMP. A. Kulikova0Yu. N. Filyushkin1D. A. Kulikov2A. V. Fedulov3A. E. Mashkov4A. V. Kulikov5Lomonosov Moscow State University Moscow Regional Research and Clinical Institute (MONIKI)Moscow Regional Research and Clinical Institute (MONIKI)Moscow Regional Research and Clinical Institute (MONIKI) Institute of Theoretical and Experimental Biophysics of RASMoscow Regional Research and Clinical Institute (MONIKI)Moscow Regional Research and Clinical Institute (MONIKI)Institute of Theoretical and Experimental Biophysics of RASBackground: Development of the new methods of treatment of primary male hypogonadism is an urgent medical problem. Its solution requires a suitable experimental model of the disease. Aim: The creation of new experimental model of primary male hypogonadism. Materials and methods: The study was conducted on the male Wistar rats, hypogonadism was modeled by temporary ligation of the distal part of the spermatic cord. Results: It was shown that three-day ligation of the spermatic cord led to persistent disturbance of the testosterone-producing and reproductive functions. These manifestations were reversible at shorter duration of the exposure. Conclusion: The created model of primary male hypogonadism is characterized by the persistent testosterone-producing and reproductive functions disturbance, technical availability, non-toxicity to the other organs and systems. Availability of the model provides new opportunities for the development of approaches to treating diseases of the reproductive organs in men.https://www.almclinmed.ru/jour/article/view/53hypogonadismexperimental modeltesticlestestosteroneischemiainfertility |
| spellingShingle | P. A. Kulikova Yu. N. Filyushkin D. A. Kulikov A. V. Fedulov A. E. Mashkov A. V. Kulikov EXPERIMENTAL MODEL OF THE PRIMARY MALE HYPOGONADISM Alʹmanah Kliničeskoj Mediciny hypogonadism experimental model testicles testosterone ischemia infertility |
| title | EXPERIMENTAL MODEL OF THE PRIMARY MALE HYPOGONADISM |
| title_full | EXPERIMENTAL MODEL OF THE PRIMARY MALE HYPOGONADISM |
| title_fullStr | EXPERIMENTAL MODEL OF THE PRIMARY MALE HYPOGONADISM |
| title_full_unstemmed | EXPERIMENTAL MODEL OF THE PRIMARY MALE HYPOGONADISM |
| title_short | EXPERIMENTAL MODEL OF THE PRIMARY MALE HYPOGONADISM |
| title_sort | experimental model of the primary male hypogonadism |
| topic | hypogonadism experimental model testicles testosterone ischemia infertility |
| url | https://www.almclinmed.ru/jour/article/view/53 |
| work_keys_str_mv | AT pakulikova experimentalmodeloftheprimarymalehypogonadism AT yunfilyushkin experimentalmodeloftheprimarymalehypogonadism AT dakulikov experimentalmodeloftheprimarymalehypogonadism AT avfedulov experimentalmodeloftheprimarymalehypogonadism AT aemashkov experimentalmodeloftheprimarymalehypogonadism AT avkulikov experimentalmodeloftheprimarymalehypogonadism |