Possible role of autophagy induced by COVID-19 in cancer progression, chemo-resistance, and tumor recurrence
Abstract COVID-19 infection is a serious threat to patients with primary diseases, especially multiple cancers. Studies suggest that cancer patients are one of the most susceptible populations to experience severe COVID-19 and death. In addition, a number of studies suggest various mechanisms for SA...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | Infectious Agents and Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13027-022-00450-2 |
| _version_ | 1817969604629102592 |
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| author | Hamidreza Zalpoor Abdullatif Akbari Negar Nayerain Jazi Mahsa Liaghat Maryam Bakhtiyari |
| author_facet | Hamidreza Zalpoor Abdullatif Akbari Negar Nayerain Jazi Mahsa Liaghat Maryam Bakhtiyari |
| author_sort | Hamidreza Zalpoor |
| collection | DOAJ |
| description | Abstract COVID-19 infection is a serious threat to patients with primary diseases, especially multiple cancers. Studies suggest that cancer patients are one of the most susceptible populations to experience severe COVID-19 and death. In addition, a number of studies suggest various mechanisms for SARS-CoV-2 in cancer progression. In this study, we discussed the role of SARS-CoV-2 in the induction of autophagy and we hypothesized that autophagy induced by COVID-19 not only can contribute to viral replication but also potentially can lead to cancer progression, chemo-resistance, and tumor recurrence in multiple cancer patients. Therefore, targeting autophagy-related signaling pathways and cellular and molecular processes could be a potentially promising therapeutic approach for cancer patients with COVID-19. Hence, this study can shed light on a new window on the management of such patients. However, more investigations in the future are required to understand other pathological effects of COVID-19 infection on cancer patients to provide new therapeutic strategies to combat these complications in these patients. |
| first_indexed | 2024-04-13T20:24:10Z |
| format | Article |
| id | doaj.art-cc0c511d4d4e4109ac40f5509153feb2 |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-04-13T20:24:10Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj.art-cc0c511d4d4e4109ac40f5509153feb22022-12-22T02:31:27ZengBMCInfectious Agents and Cancer1750-93782022-07-011711410.1186/s13027-022-00450-2Possible role of autophagy induced by COVID-19 in cancer progression, chemo-resistance, and tumor recurrenceHamidreza Zalpoor0Abdullatif Akbari1Negar Nayerain Jazi2Mahsa Liaghat3Maryam Bakhtiyari4Shiraz Neuroscience Research Center, Shiraz University of Medical SciencesShiraz Neuroscience Research Center, Shiraz University of Medical SciencesDepartment of Bacteriology and Virology, School of Medicine, Shiraz University of Medical SciencesNetwork of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education & Research Network (USERN)Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education & Research Network (USERN)Abstract COVID-19 infection is a serious threat to patients with primary diseases, especially multiple cancers. Studies suggest that cancer patients are one of the most susceptible populations to experience severe COVID-19 and death. In addition, a number of studies suggest various mechanisms for SARS-CoV-2 in cancer progression. In this study, we discussed the role of SARS-CoV-2 in the induction of autophagy and we hypothesized that autophagy induced by COVID-19 not only can contribute to viral replication but also potentially can lead to cancer progression, chemo-resistance, and tumor recurrence in multiple cancer patients. Therefore, targeting autophagy-related signaling pathways and cellular and molecular processes could be a potentially promising therapeutic approach for cancer patients with COVID-19. Hence, this study can shed light on a new window on the management of such patients. However, more investigations in the future are required to understand other pathological effects of COVID-19 infection on cancer patients to provide new therapeutic strategies to combat these complications in these patients.https://doi.org/10.1186/s13027-022-00450-2COVID-19SARS-CoV-2AutophagyCancer progressionTumor recurrenceChemo-resistance |
| spellingShingle | Hamidreza Zalpoor Abdullatif Akbari Negar Nayerain Jazi Mahsa Liaghat Maryam Bakhtiyari Possible role of autophagy induced by COVID-19 in cancer progression, chemo-resistance, and tumor recurrence Infectious Agents and Cancer COVID-19 SARS-CoV-2 Autophagy Cancer progression Tumor recurrence Chemo-resistance |
| title | Possible role of autophagy induced by COVID-19 in cancer progression, chemo-resistance, and tumor recurrence |
| title_full | Possible role of autophagy induced by COVID-19 in cancer progression, chemo-resistance, and tumor recurrence |
| title_fullStr | Possible role of autophagy induced by COVID-19 in cancer progression, chemo-resistance, and tumor recurrence |
| title_full_unstemmed | Possible role of autophagy induced by COVID-19 in cancer progression, chemo-resistance, and tumor recurrence |
| title_short | Possible role of autophagy induced by COVID-19 in cancer progression, chemo-resistance, and tumor recurrence |
| title_sort | possible role of autophagy induced by covid 19 in cancer progression chemo resistance and tumor recurrence |
| topic | COVID-19 SARS-CoV-2 Autophagy Cancer progression Tumor recurrence Chemo-resistance |
| url | https://doi.org/10.1186/s13027-022-00450-2 |
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