SDF‐1α (Stromal Cell‐Derived Factor 1α) Induces Cardiac Fibroblasts, Renal Microvascular Smooth Muscle Cells, and Glomerular Mesangial Cells to Proliferate, Cause Hypertrophy, and Produce Collagen

SDF‐1α (Stromal Cell‐Derived Factor 1α) Induces Cardiac Fibroblasts, Renal Microvascular Smooth Muscle Cells, and Glomerular Mesangial Cells to Proliferate, Cause Hypertrophy, and Produce Collagen

BackgroundActivated cardiac fibroblasts (CFs), preglomerular vascular smooth muscle cells (PGVSMCs), and glomerular mesangial cells (GMCs) proliferate, cause hypertrophy, and produce collagen; in this way, activated CFs contribute to cardiac fibrosis, and activated PGVSMCs and GMCs promote renal fib...

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Bibliographic Details
Main Authors: Edwin K. Jackson, Yumeng Zhang, Delbert D. Gillespie, Xiao Zhu, Dongmei Cheng, Travis C. Jackson
Format: Article
Language:English
Published: Wiley 2017-11-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiac fibroblasts
C‐X‐C motif chemokine receptor 4
dipeptidyl peptidase 4
fibroblasts
glomerular mesangial cells
hypertension
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.007253

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