Association between <i>APOE</i> Genotype with Body Composition and Cardiovascular Disease Risk Markers Is Modulated by BMI in Healthy Adults: Findings from the BODYCON Study
Body mass index (BMI) has been suggested to play an important role in the relationship between the <i>APOLIPOPROTEIN</i> (<i>APO)E</i> genotype and cardiovascular disease (CVD) risk. Using data from the BODYCON cross-sectional study (n = 360 adults) we assessed the associatio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/17/9766 |
| Summary: | Body mass index (BMI) has been suggested to play an important role in the relationship between the <i>APOLIPOPROTEIN</i> (<i>APO)E</i> genotype and cardiovascular disease (CVD) risk. Using data from the BODYCON cross-sectional study (n = 360 adults) we assessed the association between body composition and CVD risk markers according to <i>APOE</i> genotype, with examination of the role of BMI. In this study cohort, the <i>APOE2/E3</i> group had lower fasting blood lipids than <i>APOE4</i> carriers and <i>APOE3/E3</i> group (<i>p</i> ≤ 0.01). After stratifying the group according to BMI, <i>APOE4</i> carriers in the normal BMI subgroup had a higher lean mass compared with the <i>APOE3/E3</i> group (<i>p</i> = 0.02) whereas in the overweight/obese subgroup, the android to gynoid percentage fat ratio was lower in <i>APOE4</i> carriers than <i>APOE3/E3</i> group (<i>p</i> = 0.04). Fasting lipid concentrations were only different between the <i>APOE2/E3</i> and other genotype groups within the normal weight BMI subgroup (<i>p</i> ≤ 0.04). This finding was associated with a lower dietary fibre and a higher trans-fat intake compared with <i>APOE4</i> carriers, and a lower carbohydrate intake relative to the <i>APOE3/E3</i> group. Our results confirm previous reports that BMI modulates the effect of <i>APOE</i> on CVD risk markers and suggest novel interactions on body composition, with diet a potential modulator of this relationship. |
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| ISSN: | 1661-6596 1422-0067 |