Blocking sense‐strand activity improves potency, safety and specificity of anti‐hepatitis B virus short hairpin RNA

Blocking sense‐strand activity improves potency, safety and specificity of anti‐hepatitis B virus short hairpin RNA

Abstract Hepatitis B virus (HBV) is a promising target for therapies based on RNA interference (RNAi) since it replicates via RNA transcripts that are vulnerable to RNAi silencing. Clinical translation of RNAi technology, however, requires improvements in potency, specificity and safety. To this end...

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Bibliographic Details
Main Authors: Thomas Michler, Stefanie Große, Stefan Mockenhaupt, Natalie Röder, Ferdinand Stückler, Bettina Knapp, Chunkyu Ko, Mathias Heikenwalder, Ulrike Protzer, Dirk Grimm
Format: Article
Language:English
Published: Springer Nature 2016-09-01
Series:EMBO Molecular Medicine
Subjects:
Adeno‐associated virus
hepatitis B virus
RNA interference
short hairpin RNA
tough decoy
Online Access:https://doi.org/10.15252/emmm.201506172

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