Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids

Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids

Vitamin A (VA) plays an essential role in modulating both the gut microbiota and gut barrier function. Short-chain fatty acids (SCFAs), as metabolites of the gut microbiota, protect the physiological intestinal barrier; however, they are compromised when VA is deficient. Thus, there is an urgent nee...

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Bibliographic Details
Main Authors: Junyan Yan, Lu Xiao, Di Feng, Baolin Chen, Ting Yang, Bei Tong, Ruifang Luo, Yuting Wang, Jie Chen
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-03-01
Series:Genes and Diseases
Subjects:
CEACAM1
Colonic epithelial barrier
HDAC3
Short-chain fatty acids
Vitamin A deficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304223002064

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