Untargeted metabolomics to evaluate polymyxin B toxicodynamics following direct intracerebroventricular administration into the rat brain

Untargeted metabolomics to evaluate polymyxin B toxicodynamics following direct intracerebroventricular administration into the rat brain

There is a dearth of studies focused on understanding pharmacokinetics, pharmacodynamics and toxicodynamics of polymyxins following direct administration to the central nervous system (CNS). In this study, for the first time, untargeted metabolomics were employed to ascertain the perturbations of br...

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Bibliographic Details
Main Authors: Maytham Hussein, Sara Oberrauch, Rafah Allobawi, Linda Cornthwaite-Duncan, Jing Lu, Rajnikant Sharma, Mark Baker, Jian Li, Gauri G. Rao, Tony Velkov
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Polymyxin B
CNS toxicity
Metabolomics
Intraventricular injection
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022004883

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