Frequency and neural correlates of pauses in patients with formal thought disorder
Background: Pauses during speech may reflect the planning and monitoring of discourse, two processes putatively impaired in patients with schizophrenia, particularly those with formal thought disorder (FTD). We used functional MRI to examine the neural correlates of between-clause and of filled paus...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-10-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00127/full |
| _version_ | 1811227243711561728 |
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| author | Kazunori eMatsumoto Kazunori eMatsumoto TIlo eKircher Paul eStokes Mickael J. Brammer Peter eLIddle Philip K McGuire |
| author_facet | Kazunori eMatsumoto Kazunori eMatsumoto TIlo eKircher Paul eStokes Mickael J. Brammer Peter eLIddle Philip K McGuire |
| author_sort | Kazunori eMatsumoto |
| collection | DOAJ |
| description | Background: Pauses during speech may reflect the planning and monitoring of discourse, two processes putatively impaired in patients with schizophrenia, particularly those with formal thought disorder (FTD). We used functional MRI to examine the neural correlates of between-clause and of filled pauses, which are respectively associated with speech planning and speech monitoring. Methods: BOLD contrast was measured while 6 schizophrenia patients with FTD and 6 healthy subjects spoke about Rorshach inkblots. In an event-related design, we examined activity associated with pauses that occurred between clauses and with pauses that were filled. Results: There was no significant group difference in the frequency of between-clause pauses but patients with FTD made strikingly fewer filled pauses than controls. Between-clause pauses were associated with activation in the anterior part of the left superior temporal gyrus (STG) and the left insula in controls and the engagement of these regions was significantly attenuated in patients. Conclusions: The anterior part of the left STG and the left insula are normally involved in both the planning and monitoring of discourse. The attenuated engagement of these regions with between-clause pauses and the striking infrequency of filled pauses in the patients are consistent with cognitive models implicating defective speech planning and speech monitoring in schizophrenia, especially in relation to FTD. |
| first_indexed | 2024-04-12T09:39:20Z |
| format | Article |
| id | doaj.art-cc11206ed13c4c3b9321c5dc4a9cd3b8 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-12T09:39:20Z |
| publishDate | 2013-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-cc11206ed13c4c3b9321c5dc4a9cd3b82022-12-22T03:38:08ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402013-10-01410.3389/fpsyt.2013.0012759101Frequency and neural correlates of pauses in patients with formal thought disorderKazunori eMatsumoto0Kazunori eMatsumoto1TIlo eKircher2Paul eStokes3Mickael J. Brammer4Peter eLIddle5Philip K McGuire6Institute of Psychiatry, King’s College LondonTohoku University Graduate School of MedicinePhilipps-University MarburgInstitute of Psychiatry, King’s College LondonInstitute of Psychiatry, King’s College LondonUniversity of NottinghamInstitute of Psychiatry, King’s College LondonBackground: Pauses during speech may reflect the planning and monitoring of discourse, two processes putatively impaired in patients with schizophrenia, particularly those with formal thought disorder (FTD). We used functional MRI to examine the neural correlates of between-clause and of filled pauses, which are respectively associated with speech planning and speech monitoring. Methods: BOLD contrast was measured while 6 schizophrenia patients with FTD and 6 healthy subjects spoke about Rorshach inkblots. In an event-related design, we examined activity associated with pauses that occurred between clauses and with pauses that were filled. Results: There was no significant group difference in the frequency of between-clause pauses but patients with FTD made strikingly fewer filled pauses than controls. Between-clause pauses were associated with activation in the anterior part of the left superior temporal gyrus (STG) and the left insula in controls and the engagement of these regions was significantly attenuated in patients. Conclusions: The anterior part of the left STG and the left insula are normally involved in both the planning and monitoring of discourse. The attenuated engagement of these regions with between-clause pauses and the striking infrequency of filled pauses in the patients are consistent with cognitive models implicating defective speech planning and speech monitoring in schizophrenia, especially in relation to FTD.http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00127/fullLanguageSchizophreniafMRIspeech monitoringformal thought disorderpause |
| spellingShingle | Kazunori eMatsumoto Kazunori eMatsumoto TIlo eKircher Paul eStokes Mickael J. Brammer Peter eLIddle Philip K McGuire Frequency and neural correlates of pauses in patients with formal thought disorder Frontiers in Psychiatry Language Schizophrenia fMRI speech monitoring formal thought disorder pause |
| title | Frequency and neural correlates of pauses in patients with formal thought disorder |
| title_full | Frequency and neural correlates of pauses in patients with formal thought disorder |
| title_fullStr | Frequency and neural correlates of pauses in patients with formal thought disorder |
| title_full_unstemmed | Frequency and neural correlates of pauses in patients with formal thought disorder |
| title_short | Frequency and neural correlates of pauses in patients with formal thought disorder |
| title_sort | frequency and neural correlates of pauses in patients with formal thought disorder |
| topic | Language Schizophrenia fMRI speech monitoring formal thought disorder pause |
| url | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00127/full |
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