Correlation between disease activity and serum interleukin-23 in rheumatoid arthritis
Background Interleukin-23 (IL-23) is a proinflammatory cytokine that is thought to be central to the development of autoimmune diseases. This study was conducted to determine whether or not serum concentration of IL-23 is elevated in patients with rheumatoid arthritis (RA) and to determine the rela...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2017-01-01
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| Series: | Egyptian Rheumatology and Rehabilitation |
| Subjects: | |
| Online Access: | http://www.err.eg.net/article.asp?issn=1110-161X;year=2017;volume=44;issue=3;spage=118;epage=124;aulast=Fadda |
| _version_ | 1819156055137976320 |
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| author | Samia H Fadda Mervat I Abd Elazeem Rabab A Mohammed Marwa T Sayed |
| author_facet | Samia H Fadda Mervat I Abd Elazeem Rabab A Mohammed Marwa T Sayed |
| author_sort | Samia H Fadda |
| collection | DOAJ |
| description | Background
Interleukin-23 (IL-23) is a proinflammatory cytokine that is thought to be central to the development of autoimmune diseases.
This study was conducted to determine whether or not serum concentration of IL-23 is elevated in patients with rheumatoid arthritis (RA) and to determine the relationship between the IL-23 level and disease activity in patients with RA.
Patients and methods
Serum samples were obtained from 100 patients with RA and 50 healthy controls. Clinical parameters of the disease were determined, including 28-Joint Disease Activity Score, Clinical Disease Activity Index, Health Assessment Questionnaires, C-reactive protein, rheumatoid factor levels, anti-cyclic citrullinated peptide antibodies, and degree of bony erosions based on radiographs. The levels of IL-23 were determined by enzyme-linked immunosorbent assay (ELISA). The correlations between the serum levels of IL-23 and disease activity parameters of patients with RA were determined.
Results
Serum IL-23 level was significantly elevated in patients with RA, 0.00–49.30 pg/ml (19.12±13.45 pg/ml) compared with healthy controls, 0.00–1.40 pg/ml (0.90±0.63 pg/ml) (P=0.0001). Serum IL-23 levels in patients with RA correlated with Clinical Disease Activity Index (r=0.952, P=0.000), Health Assessment Questionnaires (r=0.953, P=0.000), and 28-Joint Disease Activity Score (r=0.967, P=0.000). Moreover, serum IL-23 levels in patients with RA correlated with erythrocyte sedimentation rate (r=0.950, P=0.000), C-reactive protein (r=0.954, P=0.001), and rheumatoid factor (r=0.917, P=0.000). There was a statistically significant difference between IL-23 mean values associated with different radiograph classes in patients with RA (P=0.001).
Conclusion
Levels of serum IL-23 in patients with RA were significantly higher than in healthy controls. Moreover, elevated serum IL-23 levels were correlated with clinical and laboratory parameters of disease activity. It should be considered as a useful marker to detect active RA. IL-23 is involved in disease progression and bony erosions in patients with RA. Anti-IL-23 drugs could have a potential role in the treatment of RA. |
| first_indexed | 2024-12-22T15:46:47Z |
| format | Article |
| id | doaj.art-cc1354535dd74c51a824d64bdedb0c9c |
| institution | Directory Open Access Journal |
| issn | 1110-161X 2090-3235 |
| language | English |
| last_indexed | 2024-12-22T15:46:47Z |
| publishDate | 2017-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Rheumatology and Rehabilitation |
| spelling | doaj.art-cc1354535dd74c51a824d64bdedb0c9c2022-12-21T18:21:00ZengSpringerOpenEgyptian Rheumatology and Rehabilitation1110-161X2090-32352017-01-0144311812410.4103/err.err_11_17Correlation between disease activity and serum interleukin-23 in rheumatoid arthritisSamia H FaddaMervat I Abd ElazeemRabab A MohammedMarwa T SayedBackground Interleukin-23 (IL-23) is a proinflammatory cytokine that is thought to be central to the development of autoimmune diseases. This study was conducted to determine whether or not serum concentration of IL-23 is elevated in patients with rheumatoid arthritis (RA) and to determine the relationship between the IL-23 level and disease activity in patients with RA. Patients and methods Serum samples were obtained from 100 patients with RA and 50 healthy controls. Clinical parameters of the disease were determined, including 28-Joint Disease Activity Score, Clinical Disease Activity Index, Health Assessment Questionnaires, C-reactive protein, rheumatoid factor levels, anti-cyclic citrullinated peptide antibodies, and degree of bony erosions based on radiographs. The levels of IL-23 were determined by enzyme-linked immunosorbent assay (ELISA). The correlations between the serum levels of IL-23 and disease activity parameters of patients with RA were determined. Results Serum IL-23 level was significantly elevated in patients with RA, 0.00–49.30 pg/ml (19.12±13.45 pg/ml) compared with healthy controls, 0.00–1.40 pg/ml (0.90±0.63 pg/ml) (P=0.0001). Serum IL-23 levels in patients with RA correlated with Clinical Disease Activity Index (r=0.952, P=0.000), Health Assessment Questionnaires (r=0.953, P=0.000), and 28-Joint Disease Activity Score (r=0.967, P=0.000). Moreover, serum IL-23 levels in patients with RA correlated with erythrocyte sedimentation rate (r=0.950, P=0.000), C-reactive protein (r=0.954, P=0.001), and rheumatoid factor (r=0.917, P=0.000). There was a statistically significant difference between IL-23 mean values associated with different radiograph classes in patients with RA (P=0.001). Conclusion Levels of serum IL-23 in patients with RA were significantly higher than in healthy controls. Moreover, elevated serum IL-23 levels were correlated with clinical and laboratory parameters of disease activity. It should be considered as a useful marker to detect active RA. IL-23 is involved in disease progression and bony erosions in patients with RA. Anti-IL-23 drugs could have a potential role in the treatment of RA.http://www.err.eg.net/article.asp?issn=1110-161X;year=2017;volume=44;issue=3;spage=118;epage=124;aulast=Faddaanti-cyclic citrullinated peptideClinical Disease Activity Indexenzyme-linked immunosorbent assayinterleukin-2328-Joint Disease Activity Scorerheumatoid arthritis |
| spellingShingle | Samia H Fadda Mervat I Abd Elazeem Rabab A Mohammed Marwa T Sayed Correlation between disease activity and serum interleukin-23 in rheumatoid arthritis Egyptian Rheumatology and Rehabilitation anti-cyclic citrullinated peptide Clinical Disease Activity Index enzyme-linked immunosorbent assay interleukin-23 28-Joint Disease Activity Score rheumatoid arthritis |
| title | Correlation between disease activity and serum interleukin-23 in rheumatoid arthritis |
| title_full | Correlation between disease activity and serum interleukin-23 in rheumatoid arthritis |
| title_fullStr | Correlation between disease activity and serum interleukin-23 in rheumatoid arthritis |
| title_full_unstemmed | Correlation between disease activity and serum interleukin-23 in rheumatoid arthritis |
| title_short | Correlation between disease activity and serum interleukin-23 in rheumatoid arthritis |
| title_sort | correlation between disease activity and serum interleukin 23 in rheumatoid arthritis |
| topic | anti-cyclic citrullinated peptide Clinical Disease Activity Index enzyme-linked immunosorbent assay interleukin-23 28-Joint Disease Activity Score rheumatoid arthritis |
| url | http://www.err.eg.net/article.asp?issn=1110-161X;year=2017;volume=44;issue=3;spage=118;epage=124;aulast=Fadda |
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